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C2743
Citocalasina B
Ready Made Solution, 10 mg/mL in DMSO
Sinônimo(s):
Fomina
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200 μL
R$ 1.634,00
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200 μL
R$ 1.634,00
About This Item
Fórmula empírica (Notação de Hill):
C29H37NO5
Número CAS:
Peso molecular:
479.61
Beilstein:
1096207
Número MDL:
Código UNSPSC:
51102829
ID de substância PubChem:
NACRES:
NA.85
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Nível de qualidade
Formulário
solution
concentração
10 mg/mL in DMSO
espectro de atividade do antibiótico
fungi
Modo de ação
cell membrane | interferes
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
InChI
1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
chave InChI
GBOGMAARMMDZGR-TYHYBEHESA-N
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Categorias relacionadas
Aplicação
Cytochalasin B from Drechslera dematioidea has been used:
- to block cytokinesis, to obtain binucleated cells[1]
- as a specific glucose transporter inhibitor[2]
- to inhibit glucose transport by class I and III GLUTs to determine the 50% inhibitory concentration (IC50) in HCMV-infected and mock-infected cells[3]
Ações bioquímicas/fisiológicas
Um de um grupo de metabólitos fúngicos que interferem em uma ampla variedade de movimentos celulares. Ferramenta útil para caracterizar algumas das propriedades de polimerização da actina, e em estudos sobre citocinese. Sonda para os dois sintomas de transporte de hexose em mioblastos de rato L6.
Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
Cytochalasin B can prevent cytoplasmic division without affecting nuclear division.[7]
Outras notas
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral
Código de classe de armazenamento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
185.0 °F - closed cup - Solvent
Ponto de fulgor (°C)
85 °C - closed cup - Solvent
Equipamento de proteção individual
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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What is the Department of Transportation shipping information for this product?
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Is Product C2743, Cytochalasin B, cell culture grade?
1 answer-
The product has been sterile filtered, but it has not been cell culture tested by Sigma.
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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I have a solution of Product C2743, Cytochalasin B, in DMSO. Is the DMSO toxic to cultured cells?
1 answer-
At a low enough concentration, the DMSO should not hurt the cells. The final concentration of DMSO in the aqueous working medium typically should not exceed 0.1% because higher DMSO concentrations can adversely affect many cultured cells. Dilute the product in the appropriate aqueous medium to provide a physiologically acceptable final concentration.
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