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Documentos Principais

A2093

Sigma-Aldrich

Ácido acetilsalicílico

meets USP testing specifications

Sinônimo(s):

Ácido O-acetilsalicílico, AAS, Aspirina, Ácido 2-acetoxibenzoico

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100 G
R$ 248,00
500 G
R$ 842,00

R$ 248,00


Previsão de entrega em07 de abril de 2025


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100 G
R$ 248,00
500 G
R$ 842,00

About This Item

Fórmula linear:
2-(CH3CO2)C6H4CO2H
Número CAS:
Peso molecular:
180.16
Beilstein:
779271
Número CE:
Número MDL:
Código UNSPSC:
12352106
ID de substância PubChem:
NACRES:
NA.21

R$ 248,00


Previsão de entrega em07 de abril de 2025


Solicite uma grande encomenda

Agency

USP/NF
meets USP testing specifications

Nível de qualidade

Formulário

powder or crystals

pf

134-136 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

cadeia de caracteres SMILES

CC(=O)Oc1ccccc1C(O)=O

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

chave InChI

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Informações sobre genes

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Descrição geral

Aspirin (acetylsalicylic acid) is a nonsteroidal anti-inflammatory drug.[1][2] It occurs as white crystalline powder[2] and is derived from salicylic acid.[2]

Aplicação

Aspirin has been used:
  • as a stabilizer for blood during 13,14-dihydro-15-keto-prostaglandin F2α (PGFM) measurement[3]
  • to evaluate cell viability of BV-2 microglial cell line[4]
  • in morphogenesis assay[5]

Ações bioquímicas/fisiológicas

Bloqueia a produção de prostaglandinas pela inibição da ciclo-oxigenase (prostaglandina H sintase), com maior seletividade para a isoforma COX-1. O efeito antitrombótico se deve à inibição de COX-1 nas plaquetas que bloqueiam a produção de tromboxano e a agregação de plaquetas. Atividade quimiopreventiva contra tumores colorretais e outros tumores sólidos.
Aspirin is an analgesic and antipyretic agent used in the treatment of fever and pain as in arthritis.[6] It is also associated with cardiovascular diseases.[6]

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

482.0 °F

Ponto de fulgor (°C)

250 °C

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Acetylsalicylic acid enhances the anti-inflammatory effect of fluoxetine through inhibition of NF-kB, p38-MAPK and ERK1/2 activation in lipopolysaccharide-induced BV-2 microglia cells
Yang JM, et al.
Neuroscience, 275, 296-394 (2014)
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Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How to dissolve Aspirin and minimize concentration for storage?

    1 answer
    1. This compound is soluble in ethanol at 50 mg/mL, in water at 3 mg/mL, and in 37 °C water at 10 mg/mL. Acetylsalicylic acid is not stable in aqueous solutions and will readily hydrolyze to salicylic acid. Minimal concentration and solution stability in ethanol have not been established.

      Helpful?

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