178810

Tetra-hidrofurano

≥99.0%, contains 200-400 ppm BHT as inhibitor, ReagentPlus^®

• Sinônimo(s): Oxolano, Óxido de butileno, Óxido de tetrametileno
• Fórmula empírica (Notação de Hill): C₄H₈O
• Número CAS: 109-99-9
• Peso molecular: 72.11
• Beilstein: 102391
• Número CE: 203-726-8
• Número MDL: MFCD00005356
• Código UNSPSC: 12191501
• ID de substância PubChem: 329751576
• NACRES: NA.21

Propriedades

• grau: reagent
• Nível de qualidade: 100
• densidade de vapor: 2.5 (vs air)
• pressão de vapor: 114 mmHg ( 15 °C); 143 mmHg ( 20 °C)
• linha de produto: ReagentPlus^®
• Ensaio: ≥99.0%
• Formulário: liquid
• temperatura de autoignição: 610 °F
• contém: 200-400 ppm BHT as inhibitor
• Lim. expl.: 1.8-11.8 %
• dilution: (for general lab use)
• índice de refração: n20/D 1.407 (lit.)
• pH: ~7
• p.e.: 65-67 °C (lit.)
• pf: −108 °C (lit.)
• densidade: 0.889 g/mL at 25 °C (lit.)
• cadeia de caracteres SMILES: C1CCOC1
• InChI: 1S/C4H8O/c1-2-4-5-3-1/h1-4H2
• chave InChI: WYURNTSHIVDZCO-UHFFFAOYSA-N

Descrição

Descrição geral

Tetrahydrofuran (THF) is a saturated cyclic ether mainly used as an organic solvent. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. THF constitutes the key fragment of various natural products (polyether antibiotics).[1] THF can form a double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies.[2] Butane-1,4-diol is formed as an intermediate during the synthesis of THF.[3] Hot THF is useful for the dissolution of polyvinylidene chloride (PVDV).[4]

Aplicação

Tetrahydrofuran may be used for the dissolution of poly-ε-caprolactone (PCL) and 1,3-diaminopentane, during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds[5] and acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32)- 1,3-diaminopentane (117) polymer,[6] respectively.

Outras notas

For information on tetrahydrofuran miscibility, please visit the following link:
Tetrahydrofuran Miscibility/Immiscibility Table

Greener alternatives are available for many THF applications, 2-Methyltetrahydrofuran (155810) and Cyclopentyl methyl ether (675989)

Read more about THF alternatives:
2-Methyltetrahydroun (2-MeTHF): A biomass-Derived solvent with Broad Applications in Organic Chemistry

The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent

Informações legais

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS02,GHS08,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H225,H302,H319,H335,H336,H351
• Declarações de precaução: P202 - P210 - P233 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Órgãos-alvo: Central nervous system, Respiratory system
• Perigos de suplementos: EUH019
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): -6.2 °F - closed cup
• Ponto de fulgor (°C): -21.2 °C - closed cup