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Merck

ABCB1

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Sinônimos:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Espécies:
Human ABCB1 (5243), dog ABCB1 (403879), domestic cat ABCB1 (493707), Thale Cress ABCB1 (818265), naked mole-rat Abcb1 (101702843), domestic guinea pig Abcb1 (100733532), Domestic Rabbit ABCB1 (100008914), sheep ABCB1 (443367), Horse ABCB1 (100034074), cow ABCB1 (281585)
ID UniProtKB:
P08183, A8K294, Q12755, Q14812
ID do gene:
  • Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
  • dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Thale Cress(818265) ABC transporter B family member 1
  • naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1

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Small Molecule - Agonist

Número do produto
Descrição
Espécies
150215
9(10H)-Acridanone, 99%,
Espécies
human
H0888
Hidrocortisona, BioReagent, suitable for cell culture,
Espécies
human, mouse, rat
H6909
Hydrocortisone solution, 50 μM, sterile-filtered, BioXtra, suitable for cell culture,
Espécies
human, mouse, rat
H0135
Hidrocortisona, γ-irradiated, powder, BioXtra, suitable for cell culture,
Espécies
human, mouse, rat
H4001
Hidrocortisona, ≥98% (HPLC),
Espécies
human, mouse, rat

Small Molecule - Antagonist

Número do produto
Descrição
Espécies
142662
Chlorosulfonyl isocyanate, 98%,
Espécies
human
I8898
Ivermectin, ,
Espécies
mouse, human
O104
Omeprazole, solid,
Espécies
human
E5389
Erythromycin, BioReagent, suitable for cell culture,
Espécies
mouse, human
C6019
Clotrimazole, ,
Espécies
mouse, human

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
P7965
Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse, clone F4, ascites fluid,
Reatividade de espécies
hamster, human
Aplicação
ELISA
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
radioimmunoassay
western blot
HPA002199
Anti-ABCB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunofluorescence
immunohistochemistry
MAB4120
Anti-MDR1 Antibody, clone JSB-1, culture supernatant, clone JSB-1, Chemicon®,
Reatividade de espécies
hamster, human
Aplicação
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
ZRB1521
Anti-MDR-1 Antibody, clone 1O12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reatividade de espécies
human, mouse
Aplicação
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
MAB4163
Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57, clone MC57, Chemicon®, from mouse,
Reatividade de espécies
human
Aplicação
flow cytometry
immunohistochemistry

Cell Lines

Número do produto
Descrição
Espécies
MTOX1303
Canine MDR1 Knockout, Human MDR1 Knockin MDCKII Cells, ,
Espécies
human
MTOX1012
CAR Knockout HepaRG™ Cells, 1 vial,
Espécies
MTOX1001
MDR1 Knockout Caco-2 Cells, one vial,
Espécies
human
MTOX1071
Kidney PTEC MDR1 KnockoutCells [MDR1 knock out (-/-)], ,
Espécies
human
MTOX1019
MDR1 Knockout HepaRG™ Cells, 1 vial,
Espécies
human

Kits

Número do produto
Descrição
Espécies
MAK161
Multidrug Resistance Assay Kit, (Fluorometric MDR Assay),
Espécies
human, mouse, rat

Small Molecule - Mixed Agonist/Antagonist

Número do produto
Descrição
Espécies
D4902
Dexametasona, powder, BioReagent, suitable for cell culture, ≥97%,
Espécies
mouse, rat, human
D1756
Dexametasona, ≥98% (HPLC), powder,
Espécies
mouse, rat, human
D8893
Dexametasona, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Espécies
mouse, rat, human
P7556
Progesterone-Water Soluble, powder, BioReagent, suitable for cell culture,
Espécies
mouse, human, rat
D9184
Dexametasona, meets USP testing specifications,
Espécies
mouse, rat, human

esiRNA

Número do produto
Descrição
Espécies
EHU131661
MISSION® esiRNA, targeting human ABCB1,
Espécies
human