D1756

Dexametasona

≥98% (HPLC), powder, NOS induction inhibitor

• Sinônimo(s): (11β,16α)-9-Fluoro-11,17,21-tri-hidroxi-16-metilpregna-1,4-dieno-3,20-diona, 9α-Fluoro-16α-metil-11β,17α,21-tri-hidroxi-1,4-pregnadieno-3,20-diona, 9α-Fluoro-16α-metilprednisolona, Prednisolona F
• Fórmula empírica (Notação de Hill): C₂₂H₂₉FO₅
• Número CAS: 50-02-2
• Peso molecular: 392.46
• Beilstein: 2066651
• Número CE: 200-003-9
• Número MDL: MFCD00064136
• Código UNSPSC: 51422306
• ID de substância PubChem: 24893536
• NACRES: NA.77

Propriedades

• product name: Dexametasona, ≥98% (HPLC), powder
• Nível de qualidade: 200
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: off-white
• pf: 262-264 °C (lit.)
• solubilidade: methanol: 25 mg/mL
• originador: Merck & Co., Inc., Kenilworth, NJ, U.S.
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
• InChI: 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
• chave InChI: UREBDLICKHMUKA-CXSFZGCWSA-N
• Informações sobre genes: human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908) ; mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Ptgs2(19225) , Tnf(21926) ; rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)

Descrição

Descrição geral

Dexamethasone is a potent glucocorticoid with minimal to no mineralocorticoid activity. Dexamethasone exhibits pleiotropic effects on multiple signaling pathways, some of its functions include, inhibition of neutrophil migration and reduction of lymphocyte colony proliferation. Research findings show, dexamethasone might prevent high-altitude pulmonary edema by decreasing pulmonary artery pressure.

Aplicação

Dexamethasone has been used:

• in culture media to induce differentiation of adipose-derived stem cells into osteogenic tissue
• as a component of adipocyte differentiation medium
• for in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)

Ações bioquímicas/fisiológicas

Agente anti-inflamatório glicocorticoide. Regula a sobrevivência, crescimento e diferenciação de células T. Inibe a indução de óxido nítrico sintase.

Dexamethasone is known to be effective against relapsed multiple myeloma. It is found to decrease inflammation associated with cerebrospinal fluid and central nervous system (CNS) complications, such as hearing loss.

Características e benefícios

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Nota de preparo

Dexamethasone is soluble in DMSO (25 mg/ml), chloroform or ethanol.

Reconstituição

Dilute 1 mg/ml stock solution 1:50 with sterile media and store frozen in working aliquots to avoid repeated freeze-thaw.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H360FD
• Declarações de precaução: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Repr. 1B
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves