I8898

Ivermectin

• Sinônimo(s): 22,23-Dihydroavermectin B1, MK-933
• Número CAS: 70288-86-7
• Número MDL: MFCD00869511
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278497
• NACRES: NA.77

Propriedades

• forma: powder
• Nível de qualidade: 100
• solubilidade: MEK: 50 mg/mL
• espectro de atividade do antibiótico: parasites
• aplicação(ões): agriculture; environmental
• Modo de ação: cell membrane | interferes
• originador: Merck & Co., Inc., Kenilworth, NJ, U.S.
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC
• InChI: 1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
• chave InChI: AZSNMRSAGSSBNP-XPNPUAGNSA-N
• Informações sobre genes: human ... ABCB1(5243) , CYP3A4(1576) ; mouse ... Abcb1a(18671) , Abcb1b(18669)

Descrição

Descrição geral

Ivermectin is a macro-cyclic lactone, derived from avermectin. It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases.

Aplicação

Ivermectin has been used:

• in Caenorhabditis elegans fecundity assay
• in larval development test
• to measure in vivo topical acaricide activity of compounds in rats
• to assess its acute and chronic effects to zebrafish
• in percutaneous drug injection method to treat cystic echinococcosis
• in liquid chromatography with fluorescence detection method

Ações bioquímicas/fisiológicas

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

Características e benefícios

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Outras notas

Primarily ivermectin B_1a.

Informações de segurança

• Pictogramas: GHS06,GHS08,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H300,H311,H351,H360D,H410
• Declarações de precaução: P202 - P264 - P273 - P280 - P301 + P310 - P302 + P352 + P312
• Classificações de perigo: Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1B
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges