SML1083

Ethacrynsäure

≥97% (HPLC), glutathione S-transferase inhibitor, powder

• Synonym(e): [2,3-Dichlor-4-(2-methylenbutyryl)-phenoxy]-essigsäure
• Empirische Formel (Hill-System): C₁₃H₁₂Cl₂O₄
• CAS-Nummer: 58-54-8
• Molekulargewicht: 303.14
• NACRES: NA.77
• PubChem Substance ID: 329825461
• UNSPSC Code: 12352106
• EC Number: 200-384-1
• MDL number: MFCD00056693
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Ethacrynsäure, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O
• InChI: 1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
• InChI key: AVOLMBLBETYQHX-UHFFFAOYSA-N
• Gene Information: human ... SLC12A1(6557)

Beschreibung

Biochem/physiol Actions

Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers.

Ethacrynic acid increases the cytotoxicity of chlorambucil in rat and human tumor cell lines.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable