M9292

Memantin -hydrochlorid

≥98% (GC), powder, NMDA glutamate receptor antagonist

• Synonym(e): 3,5-Dimethyl-1-adamantanamin -hydrochlorid, 3,5-Dimethyl-amantadin -hydrochlorid, 3,5-Dimethyltricyclo[3.3.1.1^3,7]decan-1-amin -hydrochlorid
• Empirische Formel (Hill-System): C₁₂H₂₁N · HCl
• CAS-Nummer: 41100-52-1
• Molekulargewicht: 215.76
• NACRES: NA.77
• PubChem Substance ID: 24277990
• UNSPSC Code: 12352200
• EC Number: 255-219-6
• MDL number: MFCD00214336
• Assay: ≥98% (GC)
• Form: powder

Eigenschaften

• Produktname: Memantin -hydrochlorid, ≥98% (GC)
• Quality Segment: 100
• assay: ≥98% (GC)
• form: powder
• originator: Forest Labs
• SMILES string: Cl.C[C@]12CC3C[C@](C)(C1)CC(N)(C3)C2
• InChI: 1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H/t9-,10+,11-,12-;
• InChI key: LDDHMLJTFXJGPI-VXMZOEJHSA-N
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Beschreibung

Application

Memantine hydrochloride has been used:

• as a media supplement to serve as a control to study the neuroprotective effects of erythropoietin in N-methyl-D-aspartate receptor-induced toxicity
• to intraperitoneally inject experimental animal to study its effect on traumatic injury
• as a test compound to determine the dynamic range and selectivity of retinal pigment epithelium tissue penetration

Biochem/physiol Actions

Low-affinity NMDA glutamate receptor antagonist; stimulates dopamine release.

Memantine is effective against Alzheimer′s disease and Parkinson′s disease. It is also useful in treating epilepsy, motor neurone disease and trauma.

Features and Benefits

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)