SML0810

MHY1485

≥95% (HPLC)

• Synonym(e): 4,6-Di-4-morpholinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
• Empirische Formel (Hill-System): C₁₇H₂₁N₇O₄
• CAS-Nummer: 326914-06-1
• Molekulargewicht: 387.39
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: [N+](=O)([O-])c1ccc(cc1)Nc2nc(nc(n2)N4CCOCC4)N3CCOCC3
• InChI: 1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)
• InChIKey: MSSXBKQZZINCRI-UHFFFAOYSA-N

Beschreibung

Anwendung

MHY1485 has been used:

• to study the effect of mammalian target of rapamycin mTOR signalling on in vitro O-GlcNAcylation[1]
• to inhibit autophagy[2]
• as a mTOR agonist to demonstrate that the O-linked N-acetylglucosamine transferase- RNA helicase p68 (OGT-DDX5) axis regulates colorectal cancer cell proliferation and metastasis[3]

Biochem./physiol. Wirkung

MHY1485 binds to the mammalian target of rapamycin (mTOR) and stimulates its action. MHY1485 has the ability to penetrate the cell.[4] It prevents the ultraviolet-induced oxidative stress in keratinocytes and fibroblasts.[5]

MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.

MHY1485 is mTOR activator: autophagy inhibitor.

Leistungsmerkmale und Vorteile

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable