SML0180

Aceclidine hydrochloride

≥98% (HPLC)

• Synonym(e): 1-Azabicyclo[2.2.2]oct-3-yl acetate hydrochloride, 3-Acetoxyquinuclidine hydrochloride
• Empirische Formel (Hill-System): C₉H₁₅NO₂ · HCl
• CAS-Nummer: 6109-70-2
• Molekulargewicht: 205.68
• EG-Nummer: 228-071-5
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825209
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to tan
• Löslichkeit: H₂O: ≥15 mg/mL at ~60 °C
• Lagertemp.: −20°C
• SMILES String: Cl.CC(=O)O[C@H]1CN2CC[C@H]1CC2
• InChI: 1S/C9H15NO2.ClH/c1-7(11)12-9-6-10-4-2-8(9)3-5-10;/h8-9H,2-6H2,1H3;1H/t9-;/m0./s1
• InChIKey: LWWSARSTZGNKGV-FVGYRXGTSA-N

Beschreibung

Anwendung

Aceclidine hydrochloride may be used in muscarinic acetylcholine receptor-mediated cell signaling studies.

Biochem./physiol. Wirkung

Aceclidine at a concentration of 5 and 50 μg is capable of enhancing the outflow facility, following ciliary muscle disinsertion.[1]

Aceclidine hydrochloride is a parasympathomimetic drug with weak anticholinesterase activity. It acts on cholinergic nerve-endings, lowers intraocular pressure and potent therapeutic agent for open-angle glaucoma.[2]

Aceclidine is a non-selective muscarinic acetylcholine receptor partial agonist that is effective in reducing intraocular pressure.

Muscarinic receptor partial agonist

Leistungsmerkmale und Vorteile

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301 + H311
• P-Sätze: P264 - P280 - P301 + P310 - P302 + P352 + P312 - P361 + P364 - P405
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable