SAB4200181

Anti-PMP70 antibody, Mouse monoclonal

clone 70-18, purified from hybridoma cell culture

• Synonym(e): Anti- ZWS2; ZELLWEGER SYNDROME 2, Anti-70 kDa Peroxisomal membrane Protein, Anti-ABCD3, Anti-ATP-binding cassette, sub-family D (ALD), member 3, Anti-PXMP1
• MDL-Nummer: MFCD01865555
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 70-18, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~70 kDa
• Speziesreaktivität: rat, mouse, human
• Verpackung: antibody small pack of 25 μL
• Erweiterte Validierung: independent; Learn more about Antibody Enhanced Validation
• Konzentration: ~1.0 mg/mL
• Methode(n): immunofluorescence: suitable; western blot: 1-2 μg/mL using whole extracts of human HepG2 or rat PC12 cells
• Isotyp: IgG1
• UniProt-Hinterlegungsnummer: P28288
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ABCD3(5825) ; mouse ... Abcd3(19299) ; rat ... Abcd3(25270)

Beschreibung

Allgemeine Beschreibung

Anti-PMP70 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma 70-18 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. The 70 kDa peroxisomal membrane protein (PMP70), also designated PXMP1 and ABCD3 or ABD3, is one of the major components of peroxisomal membranes. PMP70 belongs to the ALD subfamily of the ATP binding cassette (ABC) transporter superfamily. It is a half-size ABC integral membrane protein consisting of 6 transmembrane domains and one ATP-binding domain.

Anwendung

Anti-PMP70 antibody, Mouse monoclonal has been used in immunoblotting[1] and immunofluorescence.

Biochem./physiol. Wirkung

The 70 kDa peroxisomal membrane protein (PMP70) participates in the metabolic transport of long and very long fatty acids into peroxisomes. It forms a stable complex with the adrenoleukodystrophy protein, adrenoleukodystrophy protein (ALDP), and several other peroxisomal proteins. Mutations in the PMP70 (PXMP1) gene may cause a subset of Zellweger syndrome-2, an autosomal recessive disorder that is manifested by defective import mechanisms for peroxisomal matrix enzymes.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable