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Merck

P178

Sigma-Aldrich

Pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid) tetrasodium salt hydrate

solid, ≥98% (HPLC)

Synonym(e):

4-[[4-Formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-1,3-benzenedisulfonic acid tetrasodium salt, PPADS tetrasodium salt hydrate

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About This Item

Empirische Formel (Hill-System):
C14H10N3Na4O12PS2 · xH2O
CAS-Nummer:
Molekulargewicht:
599.31 (anhydrous basis)
MDL-Nummer:
UNSPSC-Code:
12352106
PubChem Substanz-ID:
NACRES:
NA.77

Qualitätsniveau

Assay

≥98% (HPLC)

Form

solid

Farbe

red to orange

Löslichkeit

H2O: >10 mg/mL

Lagertemp.

−20°C

SMILES String

O.[Na+].[Na+].[Na+].[Na+].Cc1nc(\N=N\c2ccc(cc2S([O-])(=O)=O)S([O-])(=O)=O)c(COP([O-])([O-])=O)c(C=O)c1O

InChI

1S/C14H14N3O12PS2.4Na.H2O/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28;;;;;/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28);;;;;1H2/q;4*+1;/p-4/b17-16+;;;;;

InChIKey

JTTDHFFNVGHDLN-YDTRVRFHSA-J

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Verwandte Kategorien

Biochem./physiol. Wirkung

Non-selective P2 purinoceptor antagonist which blocks responses at both pre- and post-junctional sites.

Leistungsmerkmale und Vorteile

This compound is featured on the P2 Receptors: P2X Ion Channel Family and P2 Receptors: P2Y G-Protein Family pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Vorsicht

Light sensitive

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Christian Kranjec et al.
Scientific reports, 11(1), 13909-13909 (2021-07-08)
Bacteriocins are ribosomally-synthesized antimicrobial peptides, showing great potential as novel treatment options for multidrug-resistant pathogens. In this study, we designed a novel hybrid bacteriocin, Hybrid 1 (H1), by combing the N-terminal part and the C-terminal part of the related bacteriocins
Marian T Namovic et al.
Current protocols in pharmacology, Chapter 9, Unit 9-Unit 9 (2012-06-12)
Adenosine triphosphate (ATP) activates two receptor superfamilies, metabotropic P2Y and ionotropic P2X receptors. The P2X receptors are nonselective cation channels that are widely expressed on excitable cells including neurons, glia, and smooth muscle cells. The protocols in this unit are
Déborah Lécuyer et al.
Frontiers in immunology, 14, 1270081-1270081 (2023-11-03)
Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood. Here, we report that the purinergic receptor P2X7 and NLRP3 inflammasome
G Lambrecht et al.
European journal of pharmacology, 217(2-3), 217-219 (1992-07-07)
We have characterized PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) as a novel antagonist which selectively blocks P2 purinoceptor-mediated responses in rabbit vas deferens at pre- and postjunctional sites. PPADS did not interact with alpha 1-adrenoceptors, muscarinic M2 and M3 receptors, histamine H1 and
Viola Donati et al.
Function (Oxford, England), 3(1), zqab064-zqab064 (2022-03-26)
The epidermis forms an essential barrier against a variety of insults. The overall goal of this study was to shed light not only on the effects of accidental epidermal injury, but also on the mechanisms that support laser skin resurfacing

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