The CMR (Carcinogenic, Mutagenic, or Reproductive toxic) classification related to this product is affected by both iron-dextran and phenol. Iron-dextran may potentially be a human carcinogen, while phenol is associated with the risk of causing genetic defects. For detailed information, please refer to Section 11.2 in the Safety Data Sheet (SDS) available at the following link: https://www.sigmaaldrich.com/sds/sigma/d8517?userType=anonymous
D8517
Eisen-Dextran
95-105 mg/mL (Iron content), solution
Synonym(e):
Ferric hydroxide dextran complex
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25 ML
€ 168,00
100 ML
€ 435,00
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25 ML
€ 168,00
100 ML
€ 435,00
About This Item
Empfohlene Produkte
Biologische Quelle
synthetic
Qualitätsniveau
Sterilität
aseptically filled
Assay
95-105 mg/mL (Iron content)
Form
solution
Enthält
0.5% phenol as preservative
Zusammensetzung
Iron, ~100 mg/mL
Farbe
brown
Nützlicher pH-Bereich
4 - 6.5
Lagertemp.
room temp
SMILES String
[Fe].[S](=O)(=O)(O)O
InChI
1S/Fe.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)
InChIKey
MVZXTUSAYBWAAM-UHFFFAOYSA-N
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Anwendung
Sonstige Hinweise
To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.
Signalwort
Danger
H-Sätze
Gefahreneinstufungen
Carc. 1B - Skin Sens. 1
Lagerklassenschlüssel
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Analysenzertifikate (COA)
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Zachariah DeFilipp et al.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 9(1), 129-132 (2012-08-08)
Iron deficiency is a major postoperative complication of Roux-en-Y gastric bypass surgery. Oral replacement can fail to correct the deficiency. Thus, recourse to parenteral iron administration might be necessary. Our objective was to evaluate the effectiveness and safety of a
Markus R Jahn et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 78(3), 480-491 (2011-03-29)
The treatment of iron deficiency anemia with polynuclear iron formulations is an established therapy in patients with chronic kidney disease but also in other disease areas like gastroenterology, cardiology, oncology, pre/post operatively and obstetrics' and gynecology. Parenteral iron formulations represent
D L Burns et al.
Nutrition (Burbank, Los Angeles County, Calif.), 11(2), 163-168 (1995-03-01)
Iron dextran was introduced more than 30 yr ago for the parenteral treatment of iron deficiency anemia that is refractory to oral therapy. Iron dextran is a preparation of ferric hydroxide complexed with a low molecular weight fraction of dextran.
Maureen M Okam et al.
American journal of hematology, 87(11), E123-E124 (2012-09-12)
Oral iron replacement is the standard therapy in iron-deficiency anemia (IDA). However, 59% of patients have gastrointestinal toxicity. With impaired iron uptake from the gastrointestinal tract (in anemia of chronic disease (ACD) or after bariatric surgery), suboptimal responsiveness to exogenous
C Egger et al.
Ultraschall in der Medizin (Stuttgart, Germany : 1980), 33(6), 587-592 (2012-11-17)
To check the feasibility of the easy quantification of tumor vascularization derived from dynamic contrast-enhanced ultrasound (DCE-US) in comparison to dynamic contrast-enhanced computed tomography (DCE-CT) in patients with hepatocellular carcinoma (HCC). 19 patients with cirrhosis and histologically proven HCC prospectively
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Is the CMR danger related to the presence of Phenol as a preservative or other components ? and/or Iron-dextran itself ?
1 answer-
Helpful?
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
Helpful?
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I am interested in the dextran concentration and the molcular weight of the dextran of the iron dextran solution (D8517)
1 answer-
The detran concentration is not determined for this product. The iron particles are coated with dextran by Ven der Waals forces, allowing them to remain in solution. The dextran used in the preparation is partically hydrolyzed and has an approximate molecular weight of 5000 daltons.
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Provide the information about concentration for this product and further solubility.
1 answer-
The product is provided as a 100 mg iron/ml solution in water, containing 0.5% phenol as a preservative. It can be further diluted in water or buffer.
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