SML1360

Cariporide

≥98% (HPLC), selective inhibitor of the Na+/H+ exchanger subtype 1, powder

• Synonym(e): HOE-642, N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)-benzamide, N-(Diaminomethylene)-4-isopropyl-3-(methylsulfonyl)benzamide
• Empirische Formel (Hill-System): C₁₂H₁₇N₃O₃S
• CAS-Nummer: 159138-80-4
• Molekulargewicht: 283.35
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825815
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Cariporide, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: NC(NC(C1=CC(S(C)(=O)=O)=C(C(C)C)C=C1)=O)=N
• InChI: 1S/C12H17N3O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18/h4-7H,1-3H3,(H4,13,14,15,16)
• InChI key: IWXNYAIICFKCTM-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Cariporide is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. Cariporide has shown cardioprotective and antiarrhythmic effects, and has recently been investigated for anticancer activity.

Cariporide is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1).

Cariporide, a sodium-hydrogen exchange inhibitor[1] can decrease the liberation of myoglobin at the time of ischemia/reperfusion and reduces the liberation of NE (norepinephrine) during ischemia.[2]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable