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M4627

Supelco

1-Methylnicotinamidchlorid

analytical standard

Synonym(e):

N-Methylnicotinic acid amide chloride

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1 G
€ 156,00

€ 156,00


Voraussichtliches Versanddatum13. April 2025


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1 G
€ 156,00

About This Item

Lineare Formel:
C7H9N2OCl
CAS-Nummer:
Molekulargewicht:
172.61
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

€ 156,00


Voraussichtliches Versanddatum13. April 2025


Bulk-Bestellung anfordern

Qualität

analytical standard

Qualitätsniveau

Assay

≥97.5%

Form

powder

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Farbe

white

Anwendung(en)

forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products

Format

neat

SMILES String

[Cl-].C[n+]1cccc(c1)C(N)=O

InChI

1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H

InChIKey

BWVDQVQUNNBTLK-UHFFFAOYSA-N

Allgemeine Beschreibung

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.

Anwendung

1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).[1]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem./physiol. Wirkung

Harnausscheideprodukt des Niacin-Metabolismus

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status
Creeke IP, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 817, 247-253 (2005)
Yoshitaka Tayama et al.
Drug metabolism and pharmacokinetics, 26(1), 94-101 (2010-11-19)
Aldehyde oxidase (AO) plays an important role in metabolizing antitumor and antiviral drugs, including methotrexate, cyclophosphamide and acyclovir. Green tea and its catechins have been shown to modulate the activities of various xenobiotic-metabolizing cytochrome P450 species, both in vivo and
Stefan Chłopicki et al.
Pharmacological reports : PR, 64(2), 369-376 (2012-06-05)
Methylnicotinamide (MNA) displays vasoprotective activity, however, the regulation of the activity of nicotinamide-N-methyltransferase (NNMT), is largely unknown. We analyze a possible involvement of IL-6 in the activation of NNMT-MNA pathway during an endurance exercise. FVB, C57Bl/6J IL6(+/+) and C57Bl/6J IL-6(-/-)
Magdalena Sternak et al.
Pharmacological reports : PR, 62(3), 483-493 (2010-07-16)
Nicotinamide N-methyltransferase (NNMT), which converts nicotinamide (NA) to 1-methylnicotinamide (MNA), is up-regulated in the cirrhotic liver. Because MNA displays PGI(2)-dependent anti-inflammatory effects, the up-regulation of NNMT may play a regulatory role in liver inflammation. In the present work, we analyzed
Jacek Miedzobrodzki et al.
Acta poloniae pharmaceutica, 67(5), 487-494 (2010-09-30)
The study was designed to demonstrate the relationship between the activity of human normal monocytes and blood platelets, to determine the metabolic activity of normal monocytes and monocytes cooperating with blood platelets in respect of their generation of reactive oxygen

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