This product is soluble in water at 50 mg/mL. For cell culture use, ultrapure water is typically preferred. Dimethyl sulfoxide (DMSO) is optional and should be used only when an organic solvent is required, with solubility up to approximately 100 mM. Please see the link below to access a sample or lot-specific Certificate of Analysis: https://www.sigmaaldrich.com/product/sigma/n0636#product-documentation
Fortfahren mit
N0636
Nicotinamid
BioReagent, suitable for cell culture, suitable for insect cell culture
Synonym(e):
Niacinamid, Nicotinsäureamid, Pyridin-3-carbonsäureamid, Vitamin B3, Vitamin PP
Anmelden zur Ansicht der Organisations- und Vertragspreise.
Größe auswählen
Ansicht ändern
| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
100 g | Warenkorb auf Verfügbarkeit prüfen | € 46,70 |
500 g | Warenkorb auf Verfügbarkeit prüfen | € 181,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C6H6N2O
CAS-Nummer:
Molekulargewicht:
122.12
UNSPSC Code:
12352205
NACRES:
NA.75
PubChem Substance ID:
EC Number:
202-713-4
Beilstein/REAXYS Number:
383619
MDL number:
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhaltenbiological source
synthetic (organic)
Quality Segment
product line
BioReagent
assay
≥98% (HPLC)
form
powder
mol wt
Mw 122.12 g/mol
technique(s)
cell culture | insect: suitable, cell culture | mammalian: suitable
color
white
mp
128-131 °C (lit.)
solubility
water: soluble 50 mg/mL, clear, colorless
SMILES string
NC(=O)c1cccnc1
InChI
1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
InChI key
DFPAKSUCGFBDDF-UHFFFAOYSA-N
Gene Information
human ... PARP1(142), SIRT2(22933)
General description
Nicotinamid (NAM), die Amidform von Vitamin B3, gehört zur Familie der Vitamine B. NAM ist in Lebensmitteln vorhanden und Bestandteil von Nicotinamidadenin-Dinukleotid (NAD) und Nicotinamidadenin-Dinukleotidphosphat (NADP). Tryptophan ist der Vorläufer für die NAM-Synthese in der Leber. NAM reguliert den Zellstoffwechsel, Redoxreaktionen, mitochondriale Funktionen und die Energieerzeugung. Es fördert die Proliferation und das Überleben von natürlichen Killerzellen. NAM dient der Neuroprotektion und unterstützt die neuronale Reifung. Es besitzt die Fähigkeit, die Blut-Hirn-Schranke zu durchdringen, und es schützt möglicherweise vor ischämischen Schlaganfällen und traumatischen Gehirnverletzungen. NAM kann bei der Behandlung der Alzheimer-, Parkinson- und Huntington-Krankheiten von therapeutischem Nutzen sein.
Application
Nicotinamid wird als Medienzusatz in Organoidkulturen von Darmstammzellen, in Plattenepithelzellkarzinomen der Speiseröhre (ESCC), in Bauchspeicheldrüsenkrebs-Organoiden und bei der Pankreasstammzellen-Induktion verwendet.
Biochem/physiol Actions
Nicotinamid ist ein Amid-Derivat von Vitamin B3 und ein PARP-Inhibitor.
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| technique(s) cell culture | insect: suitable, cell culture | mammalian: suitable | technique(s) - | technique(s) - | technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable |
| biological source synthetic (organic) | biological source synthetic | biological source - | biological source - |
| assay ≥98% (HPLC) | assay ≥99.5% (HPLC) | assay ≥98% (HPLC) | assay - |
| form powder | form powder or crystals | form powder | form solid |
| solubility water: soluble 50 mg/mL, clear, colorless | solubility - | solubility - | solubility - |
| color white | color colorless to white | color white | color - |
Still not finding the right product?
Explore all of our products under Nicotinamid
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Lagerklasse
11 - Combustible Solids
wgk
WGK 1
flash_point_f
302.0 °F - closed cup
flash_point_c
150 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Hier finden Sie alle aktuellen Versionen:
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
-
Is it best to use ultrapure water or DMSO as a solvent for making stock solution? I plan to use it for cell culture.
1 answer-
Helpful?
-
-
what is the solubility in DMSO?
1 answer-
Nicotinamide is soluble in DMSO to 100 mM.
Helpful?
-
-
What is the stability of Nicotinamide when lyophilized and in stock solution?
1 answer-
The recommended storage conditions and stability for stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month. Wherever possible, solutions should be made and used on the same day.
Helpful?
-
-
Can Nicotinamide aliquots be freeze-thawed more than once?
1 answer-
The product in solution has not been tested for stability following multiple freeze/thaw cycles. As a general practice, multiple freeze/thaw cycles are avoided.
Helpful?
-
-
How long are aliquots of a 1 M solution in DPBS or water at °70°C stable?
1 answer-
Solution stability studies at 70°C have not been performed on this product. Neutral aqueous solutions are fairly stable and may be autoclaved at 120 °C for up to 20 minutes. Solutions at an alkaline pH will be hydrolyzed to nicotinic acid. Nicotinamide is a component of several vitamin solutions used in cell culture (listed as niacinamide). These products are stored at -20°C, but are typically added to culture medium at 37°C.
Helpful?
-
-
Which is the recomiendes re test date for N0636-100g, lot SLBZ7561? Thank you.
1 answer-
This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.
Helpful?
-