This product can be stored tightly closed in room temperature and in dry conditions. This product does not contain an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.
N3376
Nicotinamid
≥98% (HPLC), powder, PARP inhibitor
Synonym(e):
Niacinamid, Nicotinsäureamid, Pyridin-3-carbonsäureamid, Vitamin B3, Vitamin PP
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100 G
€ 38,40
500 G
€ 66,00
1 KG
€ 102,00
Über diesen Artikel
Empirische Formel (Hill-System):
C6H6N2O
CAS-Nummer:
Molekulargewicht:
122.12
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
202-713-4
MDL number:
Beilstein/REAXYS Number:
383619
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Unterstützung erhaltenProduktname
Nicotinamid, ≥98% (HPLC), powder
InChI key
DFPAKSUCGFBDDF-UHFFFAOYSA-N
InChI
1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
SMILES string
NC(=O)c1cccnc1
assay
≥98% (HPLC)
form
powder
color
white
Quality Level
Gene Information
human ... PARP1(142), SIRT2(22933)
mp
128-131 °C (lit.)
application(s)
cell analysis
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Verwandte Kategorien
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥99.5% (HPLC) | assay ≥98% (HPLC) | assay - |
| form powder | form powder or crystals | form powder | form solid |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 500 |
| color white | color colorless to white | color white | color - |
| mp 128-131 °C (lit.) | mp 128-131 °C (lit.) | mp 128-131 °C (lit.) | mp 128-131 °C (sublimed) |
| application(s) cell analysis | application(s) cell analysis | application(s) - | application(s) liquid formulation |
Application
Used as a cofactor for certain enzymes
Biochem/physiol Actions
Nicotinamid ist ein Amid-Derivat von Vitamin B3 und ein PARP-Inhibitor.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Preparation Note
This product can be stored tightly closed in room temperature and in dry conditions.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Lagerklasse
11 - Combustible Solids
flash_point_f
302.0 °F - closed cup
flash_point_c
150 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Christian W Johnson et al.
Cell reports, 28(6), 1538-1550 (2019-08-08)
Ras GTPases are mutated at codons 12, 13, and 61, with different frequencies in KRas, HRas, and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of KRas-driven colorectal cancers, while observed only rarely in HRas or
Kathrin Schmeisser et al.
Nature chemical biology, 9(11), 693-700 (2013-10-01)
Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan. In contrast with recent observations, here we find that overexpression of sir-2.1, the ortholog of mammalian SirT1, does extend Caenorhabditis elegans lifespan. Sirtuins mandatorily convert NAD(+)
Robert J Motzer et al.
The Lancet. Oncology, 14(6), 552-562 (2013-04-20)
In a phase 3 trial comparing the efficacy and safety of axitinib versus sorafenib as second-line treatment for metastatic renal cell carcinoma, patients given axitinib had a longer progression-free survival (PFS). Here, we report overall survival and updated efficacy, quality
Thomas J Herzog et al.
Gynecologic oncology, 130(1), 25-30 (2013-04-18)
Sorafenib, an oral multikinase inhibitor of the VEGFR/PDGFR/Raf/MEK/ERK pathway, has shown potential activity in patients with recurrent ovarian cancer (OC). One strategy to prolong disease control and survival in patients with OC is maintenance therapy after achieving a complete response.
Ann-Lii Cheng et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(32), 4067-4075 (2013-10-02)
Open-label, phase III trial evaluating whether sunitinib was superior or equivalent to sorafenib in hepatocellular cancer. Patients were stratified and randomly assigned to receive sunitinib 37.5 mg once per day or sorafenib 400 mg twice per day. Primary end point
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Good day. I can't find storage condition and exp date. How long does N3376 stable in RT?
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