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D1435

Sigma-Aldrich

Dimethylsulfoxid

meets EP testing specifications, meets USP testing specifications

Synonym(e):

DMSO, Methylsulfoxid

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise

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500 ML
€ 355,00
1 L
€ 593,00
4 L
€ 1.460,00

€ 355,00

Voraussichtliches Versanddatum27. März 2025

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500 ML
€ 355,00
1 L
€ 593,00
4 L
€ 1.460,00

About This Item

Lineare Formel:
(CH3)2SO
CAS-Nummer:
67-68-5
Molekulargewicht:
78.13
Beilstein:
506008
EG-Nummer:
200-664-3
MDL-Nummer:
MFCD00002089
UNSPSC-Code:
12191502
PubChem Substanz-ID:
57654071
NACRES:
NA.71
Assay:
≥99.5%
Methode(n):
cryopreservation: suitable
bp:
189 °C (lit.)
Dampfdruck:
0.42 mmHg ( 20 °C)

€ 355,00

Voraussichtliches Versanddatum27. März 2025

Agentur

meets EP testing specifications
meets USP testing specifications

Qualitätsniveau

200

Dampfdichte

2.7 (vs air)

Dampfdruck

0.42 mmHg ( 20 °C)

Assay

≥99.5%

Form

liquid

Selbstzündungstemp.

573 °F

Expl.-Gr.

42 %, 63 °F

Methode(n)

cryopreservation: suitable

Verunreinigungen

≤0.1% water (Karl Fischer, USP)
≤0.2% water (Karl Fischer, EP)

Farbe

colorless

Brechungsindex

n20/D 1.478-1.479
n20/D 1.479 (lit.)

bp

189 °C (lit.)

mp (Schmelzpunkt)

16-19 °C (lit.)

Löslichkeit

H2O: miscible (completely)

Dichte

1.100-1.104 g/mL at 25 °C (relative density (EP))
1.10 g/mL (lit.)

UV-Absorption

λ: 285 nm Amax: ≤0.20
λ: 295 nm Amax: ≤0.20

SMILES String

CS(C)=O

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

InChIKey

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

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Anwendung

Dimethyl sulfoxide has been used:
  • for the dissolution of tetramethylrhodamine dye, which is used as fluorophore for fluorescence in- situ hybridization (FISH) experiments[1]
  • as a control in indirect immunofluorescent assay (IFA) of swine testicular (ST) cells[2]
  • for the suspension and separation of buccal cells[3]
  • a polar aprotic solvent used in polymerase chain reactions (PCR) and as a cryoprotectant vitrification agent for the preservation of cells, tissues and organs.

Biochem./physiol. Wirkung

Dimethyl sulfoxide (DMSO) is a low molecular weight, less hydrophilic and a freely permeable cryoprotectant.[4] It is a polar aprotic solvent used in polymerase chain reactions (PCR) and as a cryoprotectant and vitrification agent for the preservation of cells, tissues and organs.[5]

Vorsicht

Unterkühlt leicht und schmilzt langsam bei Raumtemperatur. Das verfestigte Produkt kann durch Erwärmen auf Raumtemperatur wieder verflüssigt werden, ohne dabei geschädigt zu werden.

Sonstige Hinweise

For information on dimethyl sulfoxide miscibility, please visit the following link:
Dimethyl Sulfoxide Miscibility/Immiscibility Table

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

188.6 °F - closed cup

Flammpunkt (°C)

87 °C - closed cup

Persönliche Schutzausrüstung

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
SHBS3830
SHBR8495
SHBQ2552
SHBS0423
SHBP4255

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Single-molecule mRNA detection and counting in mammalian tissue
Lyubimova A, et al.
Nature Protocols, 8(9), 1743-1743 (2013)
Low dose dimethyl sulfoxide driven gross molecular changes have the potential to interfere with various cellular processes
Tunccer S, et al.
Scientific reports, 8(1), 14828-14828 (2018)
Buccal micronucleus cytome assay: results of an intra-and inter-laboratory scoring comparison
Bolognesi C, et al.
Mutagenesis, 30(4), 545-555 (2015)
Identification of anti-viral activity of the cardenolides, Na+/K+-ATPase inhibitors, against porcine transmissible gastroenteritis virus
Yang CW, et al.
Toxicology and Applied Pharmacology, 332, 129-137 (2017)
Comparison of the effects of different cryoprotectants on stem cells from umbilical cord blood
Chen G, et al.
Stem Cells International, 2016 (2016)
Alle zugehörigen Dokumente anzeigen

Artikel

Good Cell Banking Practices

Overview of good cell banking practices for cell line cryopreservation purposes.

Questions

1–9 of 9 Questions  

  1. DMSO is sensible to light? should I use a amber glass to storage my solution? Thank you.

    1 answer

    1. DMSO is sensitive to light and should be stored in amber or other dark colored containers or wrapped in foil to minimize exposure.

      Helpful?

  2. What is the difference between Dimethyl sulfoxide (DMSO) Products. D1435 and D2438?

    1 answer

    1. Products D1435 and D2438 both meet the USP specifications. The D2438 is sterile-filtered, but D1435 is not. Furthermore, the D2438 is quality control tested for endotoxin and use-tested for cell freezing.

      Helpful?

  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  4. What is the molarity of DMSO?

    1 answer

    1. DMSO will have a molarity of 14.1M, based on a density of 1.1 g/mL and a molecular weight of 78.13 g/mol.

      Helpful?

  5. Is Dimethyl sulfoxide a sterile product?

    1 answer

    1. No, this product is not considered sterile.  Product Nos. D2560 and D2438 are sterile-filtered.

      Helpful?

  6. Does DMSO have any synthetic utility?

    1 answer

    1. DMSO has been used to oxidize thiols and disulfides to sulfonic acids, hydrolysis of epoxides, thioalkylation of phenols, and oxidation of primary alcohols and halides, and esters of primary alcohols to aldehydes.

      Helpful?

  7. Where does DMSO come from?

    1 answer

    1. DMSO is known to have been isolated from tree bark in the past. It is now a commericially synthesized solvent.

      Helpful?

  8. Dimethyl sulfoxide (DMSO) should be a liquid.  Why did it arrive as a solid?

    1 answer

    1. DMSO supercools easily, and re-melts slowly at room temperature. The melting point is 16-19 °C. The solidified product can be re-liquefied by warming to room temperature without detriment to the product.

      Helpful?

  9. What is the DMSO dissolved in?

    1 answer

    1. DMSO is not dissolved in any solvent. It is a pure chemical compound that is a liquid at room temperature.

      Helpful?

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