Testing for bovine IgG and BSA is not conducted in the final product. A purity agarose gel is performed on F2379, but quantification, testing, or reporting for IgG and BSA is not done. Additionally, the marker size used for QC testing is uncertain, and both IgG and BSA are larger than fetuin.
推薦產品
生物源
bovine serum (fetal)
形狀
lyophilized powder
技術
cell culture | mammalian: suitable
雜質
≤0.3% free N-acetylneuraminic acid
溶解度
H2O: 1 mg/mL, colorless to faint yellow or tan
UniProt登錄號
儲存溫度
2-8°C
基因資訊
bovine ... FETUB(504615)
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一般說明
應用
Fetuin from fetal bovine serum has been used:
- to synthesize primary and secondary calciprotein particles (CPP)[3]
- to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins[4]
- as a supplement in Ham′s F10 media for myoblast culture[5].
Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.
生化／生理作用
Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism.[6] It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases.[7] Fetuin has anti-inflammatory property.[2]
準備報告
Prepared by ammonium sulfate fractionation of fetal calf serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
從最近期的版本中選擇一個：
分析證明 (COA)
Lot/Batch Number
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Is there information available on the content/concentration of bovine IgG and BSA in the fetuin products F2379 and F3385 (CAS 9014-81-7)?
1 answer-
Helpful?
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How pure is this fetuin? There's a protein content % but could there be other proteins from serum present when using ammonium sulfate fractionation?
1 answer-
Product F2379 can not be considered pure Fetuin. Neither the purity, nor the identity of potential contaminating proteins, is determined.
Helpful?
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Is there a good antibody to recognize this bovine fetuin B by western blot?
1 answer-
Unfortunately, the Fetuin antibodies currently available are not tested against bovine. While fetuin is fairly conserved from bovine to human, reactivity cannot be predicted. See the links below for fetuin antibodies against human that have been testing for use in western blot.
ABN1469
https://www.sigmaaldrich.com/product/mm/abn1469SAB5701234
https://www.sigmaaldrich.com/product/sigma/sab5701234Helpful?
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