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重要文件

G9885

Sigma-Aldrich

α1 -酸性糖蛋白 来源于人类血浆

≥99% (agarose gel electrophoresis)

同義詞:

AGP, 鼻类

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.32
暫時無法取得訂價和供貨情況

生物源

human plasma

品質等級

化驗

≥99% (agarose gel electrophoresis)

形狀

powder

技術

ELISA: suitable

雜質

HIV-1/HIV-2, HCV and hepatitis B antigen, tested negative

UniProt登錄號

儲存溫度

2-8°C

基因資訊

human ... ORM1(5004)

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相關類別

一般說明

α-1-酸性糖蛋白(AGP)/血清类粘蛋白(ORM),一种糖蛋白,分子量为 41-43kDa。它被认为是人和大鼠中重要的急性期蛋白之一。AGP 可能属于脂质运载蛋白家族。[1]

應用

α人血浆中的 1-酸性糖蛋白已用于:
  • 作为带负电荷的蛋白,以研究在聚电解质多层表面上的吸附过程[2]
  • 在研究中孵育涂有纯化抗血清的平板,以通过 ELISA 研究其血清浓度[3]
  • 研究不同浓度对人免疫缺陷病毒(HIV)蛋白酶抑制剂的抗病毒活性的影响[4]

生化/生理作用

α1-酸性糖蛋白具有免疫调节作用。它能结合酸性药物(例如苯巴比妥)。[1]

準備報告

从科恩级分  VI 纯化

免責聲明

仅供研究使用。本品在法国的科研应用受到监管,包括用于进口和出口活动(法国《公共卫生法典》Public Health Code Article L 1211-1 paragraph 2)。如《公共卫生法典》所述,购买者(即最终用户)需要从法国研究部(France Ministry of Research)获得进口授权。订购此产品即代表您已确认获得合法的进口授权。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Jae Woong Choi et al.
Journal of microbiology and biotechnology, 30(9), 1297-1304 (2020-07-07)
Elevated serum levels of alpha-1-acid glycoprotein (AGP) are known to be associated with several types of cancer. In addition, some reports have indicated that changes in glycosylation of AGP are associated with cancer progression. However, changes in AGP levels of
Chenhua Zhang et al.
Analytica chimica acta, 1078, 189-199 (2019-07-31)
Silica-based lectin microcolumns were developed and optimized for the separation and analysis of glycoform fractions in alpha1-acid glycoprotein (AGP) based on both the degree of branching and level of fucosylation. Concanavalin A (Con A) and Aleuria Aurantia lectin (AAL) were
In Vitro Effect of alpha1-Acid Glycoprotein on the Anti?Human Immunodeficiency Virus (HIV) Activity of the Protease Inhibitor CGP 61755: A Comparative Study with Other Relevant HIV Protease Inhibitors
Lazdins J K, et al.
The Journal of Infectious Diseases, 175(5), 1063-1070 (1997)
Hendrik Grootaert et al.
Glycobiology, 30(9), 735-745 (2020-03-10)
The deoxy sugar l-fucose is frequently found as a glycan constituent on and outside living cells, and in mammals it is involved in a wide range of biological processes including leukocyte trafficking, histo-blood group antigenicity and antibody effector functions. The
Christopher J Day et al.
Scientific reports, 7(1), 1495-1495 (2017-05-06)
Subtilase cytotoxin (SubAB) of Escherichia coli is an AB5 class bacterial toxin. The pentameric B subunit (SubB) binds the cellular carbohydrate receptor, α2-3-linked N-glycolylneuraminic acid (Neu5Gc). Neu5Gc is not expressed on normal human cells, but is expressed by cancer cells.

Questions

  1. Please, could you tell me what are the best storage conditions once reconstituted in water, and for how long are reconstituted solutions stable?

    1 answer
    1. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for to 3 months at (-20°C).

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