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重要文件

F3004

Sigma-Aldrich

胎球蛋白 from fetal bovine serum

lyophilized powder

同義詞:

胎球蛋白 来源于胎牛血清

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About This Item

CAS號碼:
EC號碼:
MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.32
暫時無法取得訂價和供貨情況

生物源

bovine serum (fetal)

形狀

lyophilized powder

技術

HPLC: suitable
MALDI-MS: suitable

雜質

~0.2% free N-acetylneuraminic acid

UniProt登錄號

儲存溫度

2-8°C

基因資訊

bovine ... FETUB(504615)

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一般說明

胎球蛋白是从胎牛血清中提取的一种丰富的糖基化蛋白,具有运输和储存蛋白的功能。[1]它也被称为α2-Heremans-Schmid糖蛋白(AHSG),对应的分子量为64 kDa。[2]胎球蛋白属于他汀类药物,主要在肝脏合成,部分在肾脏、胎盘和舌头合成。[3]

應用

从胎牛血清中提取胎素已用于:
  • 基质辅助激光解吸/电离-质谱(MALDI-MS)和高效液相色谱-荧光检测分析(HPLC-FLD)中的标准糖蛋白[4]
  • 作为百日咳毒素疫苗碳水化合物结合试验中的配体[5]
  • 药物载体研究的胎素-A偶联金纳米颗粒(F-GNP)的合成[6]

生化/生理作用

在人类中,胎素基因的多态性与2型糖尿病和调节脂肪细胞功能有关。在肥胖和非酒精性脂肪肝(NAFLD)中观察到胎素水平升高。[2]胎球蛋白是临床诊断代谢紊乱的潜在指标。[7]

準備報告

通过凝胶过滤进一步处理F2379。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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M Demetriou et al.
The Journal of biological chemistry, 271(22), 12755-12761 (1996-05-31)
The serum glycoprotein fetuin is expressed during embryogenesis in multiple tissues including limb buds and has been shown to promote bone remodeling and stimulate cell proliferation in vitro. In this report, we demonstrate that fetuin antagonizes the antiproliferative action of
Development of an in vitro Biochemical Assay System for the Measurement of Residual Toxin Activities in Pertussis Toxin Containing Vaccines
Ting Yuen C, et al.
Journal of vaccines & vaccination, 08 (2017)
Fast purification of glycans and glycopeptides using silk-packed micropipette tip for matrix-assisted laser desorption/ionization-mass spectrometry and high-performance liquid chromatography-fluorescence detection analysis
Kayili H, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 139(2), 492-499 (2018)
Iqra Munir et al.
International journal of biological macromolecules, 101, 131-145 (2017-03-23)
Present study was conducted to establish the interaction of bovine fetuin-A to validate its binding modalities with doxorubicin (Dox). Fetuin-A was purified to highest purity and monodispersity. Green synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) has been performed giving typical
S R Fereidouni et al.
Veterinary microbiology, 135(3-4), 253-260 (2008-11-26)
Accurate identification of hemagglutinin (HA) and neuraminidase (NA) subtypes of influenza A viruses is an integral part of monitoring programs targeting avian influenza viruses (AIV). Use of highly sensitive molecular screening methods such as pan influenza-specific real-time RT-PCR (rRT-PCR) yields

Questions

  1. 製品にFetuin-Aが含まれることはありますでしょうか?

    1 answer
    1. This product is native fetuin isolated from fetal bovine serum and should contain both Fetuin A and B. The percentage of each is not determined. It is prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947). The article indicates that the preparation was carried out to obtain both alpha and beta forms of Fetuin. For more information, see https://pubmed.ncbi.nlm.nih.gov/20286396/

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