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Dokumenty

SCP0038

Sigma-Aldrich

Amyloid β 1-42 rat

≥90% (HPLC)

Synonim(y):

β-Amyloid 1-42, Amyloid for Rat, Rat Amyloid β 1-42

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About This Item

Wzór empiryczny (zapis Hilla):
C199H307N53O59S1
Masa cząsteczkowa:
4417.95
Kod UNSPSC:
12352200
NACRES:
NA.32

Próba

≥90% (HPLC)

Postać

lyophilized

skład

Peptide Content, ≥75%

warunki przechowywania

protect from light

temp. przechowywania

−20°C

Amino Acid Sequence

Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

Opis ogólny

Amyloid β (Aβ) 1-42 is the major Aβ species in the amyloid plaques that develop in the case of Alzheimer′s disease (AD). It has a cross-β structure with parallel, in-register β-sheets.

Zastosowanie

Amyloid β 1-42 rat has been used as an amyloid β (Aβ) oligomer in intracerebroventricular (ICV) injection/intra-hippocampal infusion to establish the Alzheimer′s disease (AD) model in rat.

Działania biochem./fizjol.

Amyloid β 1-42 forms amyloid fibrils more readily compared to Aβ(1–40), in vitro. Aβ1-42 injections are known to cause brain dysfunction indicating learning and memory deficits. Amyloid β (Aβ) refers to peptides derived from amyloid precursor protein that vary in length from 37–43 amino acids. Aβ(s) peptides, their peptide fragments, and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding, and mechanisms of protein cross-linking in the context of diseases such as Alzheimer′s disease and neurodegeneration.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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Jing Wang et al.
Molecular medicine reports, 23(6) (2021-04-22)
Ginkgolide B (GB), the diterpenoid lactone compound isolated from the extracts of Ginkgo biloba leaves, significantly improves cognitive impairment, but its potential pharmacological effect on astrocytes induced by β‑amyloid (Aβ)1‑42 remains to be elucidated. The present study aimed to investigate the
Enes Akyuz et al.
Biomedicines, 8(3) (2020-03-19)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a complex etiology and characterized by cognitive deficits and memory loss. The pathogenesis of AD is not yet completely elucidated, and no curative treatment is currently available. Inwardly rectifying potassium (Kir)
Volodymyr A Yavorsky et al.
Frontiers in cellular neuroscience, 17, 1132092-1132092 (2023-05-01)
One of the signs of Alzheimer's disease (AD) is the formation of β-amyloid plaques, which ultimately lead to the dysfunction of neurons with subsequent neurodegeneration. Although extensive researches have been conducted on the effects of different amyloid conformations such as
Raheleh Farahzadi et al.
ACS chemical neuroscience, 11(10), 1424-1435 (2020-04-21)
Mesenchymal stem cells (MSCs) are of particular interest because of their potential in regenerative medicine. Stem cell-based therapies cast a new hope for neurodegenerative disease treatment as a regeneration strategy, including treatment for Alzheimer's disease (AD). A multitude of cytokines
Ruo-Meng Li et al.
Neural regeneration research, 18(6), 1347-1353 (2022-12-02)
Previous studies have shown that fibroblast growth factor 13 is downregulated in the brain of both Alzheimer's disease mouse models and patients, and that it plays a vital role in the learning and memory. However, the underlying mechanisms of fibroblast
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