The impurities in this product are not identified. Please see the product specification to view tests performed for this product:
https://www.sigmaaldrich.com/specification-sheets/583/995/R101-BULK_________SIGMA____.pdf
Przejdź do
R101
Ranitidine hydrochloride
H2 histamine receptor antagonist;, solid
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 1 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 166,00 zł | |
| 5 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 504,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C13H22N4O3S · HCl
Numer CAS:
Masa cząsteczkowa:
350.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
266-333-0
MDL number:
Form:
solid
Quality level:
166,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
Ranitidine hydrochloride, solid
form
solid
Quality Level
color
tan
solubility
H2O: 1.8 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL
originator
GlaxoSmithKline
SMILES string
Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
InChI
1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
InChI key
GGWBHVILAJZWKJ-CHHCPSLASA-N
Gene Information
human ... HRH2(3274)
Application
Ranitidine hydrochloride has been used as a reference compound for the development and validation of parallel artificial membrane permeability assay (PAMPA).
Biochem/physiol Actions
H2 histamine receptor antagonist; anti-ulcer agent.
Ranitidine is mainly used to treat gastrointestinal impairment instigated by non-steroidal anti-inflammatory drugs (NSAIDs).
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Ta pozycja | |||
|---|---|---|---|
| form solid | form solid | form solid | form powder |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| solubility H2O: 1.8 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL | solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >10 mg/mL, H2O: 10 mg/mL, methanol: 28 mg/mL | solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL, H2O: insoluble, methanol: soluble | solubility H2O: slightly soluble 1.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >14 mg/mL, ethanol: soluble |
| color tan | color white | color tan | color white to beige |
| Gene Information human ... HRH2(3274) | Gene Information human ... CCKAR(886) | Gene Information human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRA6(2559) | Gene Information human ... CHRM3(1131) |
| originator GlaxoSmithKline | originator - | originator Roche | originator - |
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
Klasa składowania
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Produkty
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Abnormal angiogenesis is critically involved in tumor progression and metastasis including endometrial cancer and is regulated by microRNAs such as microRNA-101 (miR-101). We hypothesize that miR-101 expression is disrupted in endometrial cancer and modulation of miR-101 levels is sufficient to
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Neuroscience research, 158, 30-36 (2019-09-19)
We aimed to demonstrate the effects of microRNA (miR)-101 on neuropathic pain and explore the underlying mechanisms. Rat spinal microglia cells were isolated and inflammatory condition was stimulated by 24-h incubation with lipopolysaccharide (LPS). Rats were divided into 4 groups:
P W Bliss et al.
Alimentary pharmacology & therapeutics, 13(12), 1669-1674 (1999-12-14)
Gastrin release by Helicobacter pylori may be an important step in the pathway leading to duodenal ulceration. A histamine H3-receptor agonist was found to release gastrin from antral mucosal fragments; this was interpreted as being due to suppression of somatostatin
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| R101-5G | 04061836694135 |
| R101-1G | 04061836694128 |
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Do you have any data on the concentration of NDMA and NDEA in this reagent?
1 answer-
Helpful?
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こちらのラニチジン塩酸塩中には、不純物としてN-Nitrosodimethylamine (NDMA) 、N-Nitrosodiethylamine (NDEA) は含まれていますでしょうか。また、含まれている場合、その濃度についての情報はありますでしょうか。
1 answer-
The impurities in this product are not identified. Please see the product specification to view the testing performed for this product:
https://www.sigmaaldrich.com/specification-sheets/583/995/R101-BULK_________SIGMA____.pdfUnless otherwise stated this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption or application to humans or animals.
Helpful?
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