O104

Omeprazole

≥98% (HPLC), solid, gastric secretion inhibitor

• Synonim(y): 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, Antra, Losec
• Wzór empiryczny (zapis Hilla): C₁₇H₁₉N₃O₃S
• Numer CAS: 73590-58-6
• Masa cząsteczkowa: 345.42
• Numer MDL: MFCD00083192
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24897870
• NACRES: NA.77

Właściwości

• product name: Omeprazole, solid
• Postać: solid
• Poziom jakości: 100
• kolor: white
• rozpuszczalność: H₂O: 0.5 mg/mL; DMSO: >19 mg/mL; ethanol: 4.5 mg/mL
• inicjator: AstraZeneca
• temp. przechowywania: 2-8°C
• ciąg SMILES: COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C
• InChI: 1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
• Klucz InChI: SUBDBMMJDZJVOS-UHFFFAOYSA-N
• informacje o genach: human ... ABCB1(5243) , ATP4A(495) , ATP4B(496) , CYP1A2(1544)

Opis

Opis ogólny

Omeprazole is a benzimidazole derivative, a weak base and is lipophilic in nature. This compound is pH sensitive and does not exists in its original form at low pH.

Zastosowanie

Omeprazole has been used as an atypical cytochrome P450 (CYP) 1A2 inducer in Dulbecco′s modified eagle′s medium (serum free) to study the effects of inducers on CYP activities in human hepatocytes and also to compare with other classical aryl hydrocarbon receptor ligands.

Działania biochem./fizjol.

Omeprazole binds covalently to proton pump (H⁺, K⁺-ATPase) and inhibits gastric secretion. It is useful in ameliorating the effects of peptic oesophagitis, duodenal and gastric ulcer. Omeprazole is preferred over antagonists of histamine H2-receptor and ranitidine for its higher efficiency. It is also useful in treating Zollinger-Ellison syndrome.

Cechy i korzyści

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Przestroga

Hygroscopic, photosensitive

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07,GHS09
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H302,H317,H411
• Zwroty wskazujące środki ostrożności: P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves