E0162
Carboxylesterase 1 isoform c human
recombinant, expressed in baculovirus infected BTI insect cells
Synonym(s):
Carboxylesterase 1 human, carboxylesterase, esterase
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| Size/SKU | Availability | Price |
|---|---|---|
1 vial | Check Cart for Availability | $533.00 |
$533.00
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recombinant
expressed in baculovirus infected BTI insect cells
Quality Segment
form
liquid
concentration
≥0.3 mg/mL
shipped in
dry ice
storage temp.
−70°C
General description
Carboxylesterase 1 (CE1) is a member of a large multigene[1] carboxylesterase α,β-hydrolase family.[2] It is majorly expressed in the liver.[2] CE1 comprises an αβ domain, a central catalytic domain and a regulatory domain.[2]
This product is offered in a volume of 0.5 mL.
Application
Carboxylesterase 1 isoform c human has been used as a reference standard in carboxylesterase activity from the mussel for comparison of substrate specificity and inhibition studies.[3] It has also been used as a commercial recombinant protein for the methodological validation of environmental chemical-based inhibition studies.[4]
Biochem/physiol Actions
Carboxylesterase enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin.[2] They also hydrolyze long-chain fatty acid esters and thioesters. Carboxylesterase 1 (CE1) catalyzes the formation of cholesteryl esters from cholesterol and fatty acids. Through a transesterification reaction, CE1 also mediates the generation of fatty acid ethyl esters (FAEEs).[2] It also hydrolyzes aromatic and aliphatic esters with preference to small alcohol groups and bulky acyl groups.[5] CE1 metabolizes drug esters and amides carbamates. It participates in the detoxification of environmental toxicants and carcinogens and is useful in pharmacokinetic studies for evaluating pro-drugs.[6]
Other Notes
One unit will hydrolyze one nanomole of 4-nitrophenyl acetate per minute at pH 7.4 at 37 °C.
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This Item | |||
|---|---|---|---|
| recombinant expressed in baculovirus infected BTI insect cells | recombinant expressed in baculovirus infected BTI insect cells | recombinant expressed in baculovirus infected BTI insect cells | recombinant - |
| form liquid | form liquid | form liquid | form - |
| concentration ≥0.3 mg/mL | concentration 5 mg/mL | concentration - | concentration - |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. - |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in wet ice |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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