The buffer is 100 mM potassium phosphate with a pH of about 7.4.
E0287
Carboxylesterase 1 isoform b human
recombinant, expressed in baculovirus infected BTI insect cells
Synonim(y):
Carboxylesterase 1 human, carboxylesterase, esterase
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Pozwól nam pomócrecombinant
expressed in baculovirus infected BTI insect cells
Quality Level
form
liquid
specific activity
≥500 units/mg protein
concentration
5 mg/mL
weight
(0.5 ml)
shipped in
dry ice
storage temp.
−70°C
1 of 4
Ta pozycja | |||
|---|---|---|---|
| specific activity ≥500 units/mg protein | specific activity - | specific activity ≥500 units/mg protein | specific activity ≥1.0 EU/μg, 30,000 pmol/min-μg protein |
| form liquid | form liquid | form liquid | form solution |
| recombinant expressed in baculovirus infected BTI insect cells | recombinant expressed in baculovirus infected BTI insect cells | recombinant expressed in baculovirus infected BTI insect cells | recombinant expressed in mouse NSO cells |
| concentration 5 mg/mL | concentration ≥0.3 mg/mL | concentration - | concentration 0.4-0.6 mg/mL |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
General description
Carboxylesterase 1 is a member of a large multigene carboxylesterase family. These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.
Carboxylesterase (CE) belongs to serine hydrolase family. It is widely present in the human body. Five isoforms of carboxylesterase is present in humans. It is encoded by CES1 gene mapped to 16q22.2 in human chromosome.
Application
Delivers high catalytic activity, ideal for robust high-throughput screening assays including drug-drug interaction studies, and pharmacokinetic studies for evaluating pro-drugs and non-CYP pathways of elimination.
Carboxylesterase 1 isoform b human has been used in the reaction to convert Amplex red to resorufin in horse radish peroxidase and oxygen independent manner. It has also been used in the development of an emission ratiometric two-photon probe (SE1) for quantitation in situ.
Biochem/physiol Actions
Carboxylesterase (CE) is implicated in drug metabolism in liver and hepatic steatosis. Deficiency of CE in humans causes obesity, hyperlipidemia, insulin insensitivity, and cancer.
Other Notes
One unti will hydrolyze one nanomole of 4-nitrophenyl acetate per minute at pH 7.4 at 37°C
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signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Klasa składowania
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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A carboxylesterase-selective ratiometric fluorescent two-photon probe and its application to hepatocytes and liver tissues
Park SJ, et al.
Chemical Science, 7(6), 3703-3709 (2016)
Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays
Miwa S, et al.
Free Radical Biology & Medicine, 90, 173-183 (2016)
Marie C Fortin et al.
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Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| E0287-1VL | 04061838113603 |
-
What is the buffer composition the CES1 is shipped in?
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