D3897

2′-Deoxycytidine

≥99% (HPLC)

• Synonim(y): Cytosine deoxyriboside
• Wzór empiryczny (zapis Hilla): C₉H₁₃N₃O₄
• Numer CAS: 951-77-9
• Masa cząsteczkowa: 227.22
• Beilstein: 87567
• Numer WE: 213-454-1
• Numer MDL: MFCD00006547
• Kod UNSPSC: 41106305
• Identyfikator substancji w PubChem: 24893793
• NACRES: NA.51

Właściwości

• pochodzenie biologiczne: synthetic (organic)
• Próba: ≥99% (HPLC)
• Postać: powder
• rozpuszczalność: water: 50 mg/mL, clear, colorless to very faintly yellow
• temp. przechowywania: −20°C
• ciąg SMILES: NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](CO)O2
• InChI: 1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1
• Klucz InChI: CKTSBUTUHBMZGZ-SHYZEUOFSA-N

Opis

Opis ogólny

2′-Deoxycytidine (deoxyC) is one of the deoxynucleosides containing cytosine as the nucleobase. It is found in the blood, feces, and urine.

Zastosowanie

2′-Deoxycytidine has been used:

• as a substrate for Trypanosoma brucei cytidine deaminase (TbCDA) to measure its activity
• as a standard in the isolation and quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC–MS)
• to study the role of autophagy in response to oncogenes and DNA replication stress

Działania biochem./fizjol.

2′-Deoxycytidine (deoxyC) forms dCTP upon phosphorylation which is used to synthesis DNA via various DNA polymerases or reverse transcriptases. DeoxyC is the substrate for deoxycytidine deaminase (EC 3.5.4.14) which converts it into 2′-deoxyuridine. DeoxyC is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK). DeoxyC serves as a potential head and neck cancer marker.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)