AP-18 jest selektywnym blokerem kanału TRPA1. AP-18 blokuje receptory przejściowego potencjału receptora ankyryny 1 i może zmniejszać przewlekły ból związany z zapaleniem stawów. AP-18 zmniejsza nocycepcję indukowaną aldehydem cynamonowym in vivo i blokuje indukowaną zimnem i olejem musztardowym aktywację mysiego TRPA1, ale nie aktywację indukowaną kapsaicyną. AP-18 odwraca hiperalgezję mechaniczną wywołaną przez CFA u myszy
Działania biochem./fizjol.
AP-18 is a selective TRPA1 channel blocker.
AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice.
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H2O2 has a variety of actions in skin wounds but has been rarely studied in deep muscle tissue. Based on response to the transient receptor potential ankyrin 1 antagonists after plantar incision, we hypothesized that H2O2 exerts nociceptive effects via
Adipocyte lines are a useful tool for adipocyte research. Recently, a new preadipocyte line designated AP-18 was established from subcutaneous tissue of the C3H/He mouse. In this study, we further characterized AP-18 cells. Adipocyte differentiation was assessed by accumulation of
Antonie van Leeuwenhoek, 101(4), 733-742 (2011-12-28)
Four yeast strains (APSS 805, APSS 806, APSS 815 and AP-18) belonging to a novel Torulaspora species were isolated from coal mine soils of Singareni in Andhra Pradesh state, India. Another strain (PBA-22) was isolated from agricultural field soil from
Frontiers in physiology, 11, 576209-576209 (2020-11-17)
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel that is broadly expressed in sensory pathways, such as the trigeminal and vagus nerves. It is capable of detecting various irritants in inspired gasses and is activated during hypoxia.
Journal of controlled release : official journal of the Controlled Release Society, 321, 71-83 (2020-02-09)
Oxidative-stress defense system stands for the vulnerability of tumor cells because of the stronger oxidative stress existing in tumor sites. TRPA-1 has been found to be overexpressed in various tumors, related to the tumor proliferation and metastasis, and promote reactive
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