A7094

L-Asparagine monohydrate

≥98.0%, suitable for cell culture, BioReagent, non-animal source

• Synonim(y): Monohydrat asparaginy
• Wzór liniowy: NH₂COCH₂CH(NH₂)COOH · H₂O
• Numer CAS: 5794-13-8
• Masa cząsteczkowa: 150.13
• Beilstein: 1723527
• Numer WE: 200-735-9
• Numer MDL: MFCD00151038
• Kod UNSPSC: 12352209
• Identyfikator substancji w PubChem: 24891175
• NACRES: NA.26

Właściwości

• Nazwa produktu: L-Asparagine monohydrate, from non-animal source, BioReagent, suitable for cell culture, ≥98.0%
• pochodzenie biologiczne: non-animal source
• linia produktu: BioReagent
• Próba: ≥98.0%
• Formularz: powder
• aktywność optyczna: [α]20/D 33.0 to 36.3 °, c = 10 in 6 M HCl
• metody: cell culture | mammalian: suitable
• zanieczyszczenia: endotoxin, tested
• kolor: white
• mp: 233-235 °C (lit.)
• rozpuszczalność: H₂O: 20 mg/mL
• ślady kationów: Fe: ≤10 ppm; heavy metals (as Pb): ≤10 ppm; <0.1% (Ammonia (NH3))
• grupa funkcyjna: amide; amine; carboxylic acid
• temp. przechowywania: room temp
• ciąg SMILES: [H]O[H].N[C@@H](CC(N)=O)C(O)=O
• InChI: 1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1
• Klucz InChI: RBMGJIZCEWRQES-DKWTVANSSA-N

Opis

Opis ogólny

L-Asparagine is a naturally occurring amino acid found in various proteins. It is used in laboratory research for various applications, including cell culture, protein biochemistry, and nitrogen metabolism studies. Its solubility in water and role as a source of asparagine make it a versatile tool for investigating biological processes and chemical synthesis. Further, L-Asparagine residues in proteins can be crucial for protein stability, folding, and interactions.

Zastosowanie

L-Asparagine is used in cell culture media and is a component of MEM non-essential amino acids solution. L-Asparagine has been shown to enhance ornithine decarboxylase activity in cultured human colon adenocarcinoma Caco-2 cells and in cultured IEC-6 intestinal epithelial cells. Spore germination in Bacillus subtilis has been increased in the presence of L-asparagine. L-Asparagine, a proteinogenic amino acid, from non-animal source is used in biomanufacturing cell culture systems for the production of therapeutic recombinant proteins and monoclonal antibodies. It has also been used as a component of LHC basal media for the culture of human airway epithelial cells.[1]

Działania biochem./fizjol.

The amino acid L-asparagine is a structural analog of L-aspartic acid, where the side chain of the carboxylic acid moiety is amidated to give a terminal amine group.[2] This renders L-asparagine neutral at physiological pH. The amide group of asparagine is derived from glutamine,[3] in the reaction of aspartate and glutamine in the presence of ATP to yield asparagine and glutamate. In vivo, asparagine is hydrolyzed to aspartate and NH4⁺ by asparaginase.[4] Asparagine is also an important amino acid in glycopeptide bonds, via N-glycosyl linkages to the sugar rings.

Cechy i korzyści

• Suitable for Cell Culture and Biochemical research
• High-quality compound suitable for multiple research applications

Inne uwagi

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)