G8415

L-Glutamic acid

98.5-100.5%, suitable for cell culture, non-animal source, meets EP testing specifications

• Synonim(y): (S)-2-Aminopentanedioic acid, Glu
• Wzór liniowy: HO₂CCH₂CH₂CH(NH₂)CO₂H
• Numer CAS: 56-86-0
• Masa cząsteczkowa: 147.13
• Beilstein: 1723801
• Numer WE: 200-293-7
• Numer MDL: MFCD00002634
• Kod UNSPSC: 12352209
• eCl@ss: 32160406
• Identyfikator substancji w PubChem: 24895340
• NACRES: NA.26

Właściwości

• product name: L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%
• pochodzenie biologiczne: non-animal source
• agency: meets EP testing specifications
• Próba: 98.5-100.5%
• Postać: powder
• metody: cell culture | mammalian: suitable
• zanieczyszczenia: endotoxin, tested
• kolor: white
• mp: 205 °C (dec.) (lit.)
• rozpuszczalność: 1 M HCl: 100 mg/mL
• gęstość: 1.54 g/cm³ at 20 °C
• ślady anionów: chloride (Cl^-): ≤200 ppm; sulfate (SO₄^2-): ≤200 ppm
• ślady kationów: As: ≤1 ppm, passes test; Fe: ≤10 ppm, passes test; NH₄⁺: ≤200 ppm, passes test
• Zastosowanie: pharmaceutical (small molecule)
• ciąg SMILES: N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
• Klucz InChI: WHUUTDBJXJRKMK-VKHMYHEASA-N
• informacje o genach: human ... CCR2(1231) , GRIA1(2890) , GRIA2(2891) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK5(2901) , GRIN2B(2904) , GRM2(2912) , SLC1A1(6505) , SLC1A2(6506) ; rat ... Gria1(50592) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm3(24416) , Grm4(24417) , Grm5(24418) , Grm6(24419) , Grm7(81672) , Slc1a2(29482)

Opis

Zastosowanie

L-Glutamic acid has been used as a supplement in for cell culture media to culture hippocampal neurons and hT-PA (human tissue plasminogen activation) producing cell line.

Działania biochem./fizjol.

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid. Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity. It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase. Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)