PHR1057

Furosemide

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonim(y): FUR, 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
• Wzór empiryczny (zapis Hilla): C₁₂H₁₁ClN₂O₅S
• Numer CAS: 54-31-9
• Masa cząsteczkowa: 330.74
• Numer WE: 200-203-6
• Numer MDL: MFCD00010549
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329823087
• NACRES: NA.24

Właściwości

• klasa czystości: certified reference material; pharmaceutical secondary standard
• Poziom jakości: 300
• agency: traceable to BP 547; traceable to Ph. Eur. F0700000; traceable to USP 1287008
• rodzina API: furosemide
• Certyfikat analizy: current certificate can be downloaded
• metody: HPLC: suitable; gas chromatography (GC): suitable
• mp: 220 °C (dec.) (lit.)
• Zastosowanie: forensics and toxicology; pharmaceutical (small molecule)
• Format: neat
• temp. przechowywania: 2-30°C
• ciąg SMILES: NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
• InChI: 1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
• Klucz InChI: ZZUFCTLCJUWOSV-UHFFFAOYSA-N
• informacje o genach: human ... SLC12A1(6557)

Opis

Opis ogólny

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Furosemide is a diuretic drug, which finds a variety of therapeutic applications such as hepatic cirrhosis, cardiac insufficiency and arterial hypertension.[1]

Zastosowanie

Furosemide may also be used as a reference standard in determining the concentration of furosemide present in human urine samples using gas chromatography coupled with mass spectrometry (GC-MS).[2] Furosemide may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using diffuse reflectance spectroscopy.[3]

Furosemide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by fluorimetry,[4] spectrophotometry[5][6] and high performance liquid chromatography (HPLC).[6][7]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Działania biochem./fizjol.

Inhibits ion co-transport in the kidney.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAA7130 in the slot below. This is an example certificate only and may not be the lot that you receive.

Polecane produkty

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302,H360FD
• Zwroty wskazujące środki ostrożności: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Repr. 1B
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable