PHR1034

Lidocaine

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonim(y): 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine
• Wzór empiryczny (zapis Hilla): C₁₄H₂₂N₂O
• Numer CAS: 137-58-6
• Masa cząsteczkowa: 234.34
• Numer WE: 205-302-8
• Numer MDL: MFCD00026733
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329823064
• NACRES: NA.24

Właściwości

• klasa czystości: certified reference material; pharmaceutical secondary standard
• Poziom jakości: 300
• agency: traceable to BP 727; traceable to Ph. Eur. L0595000; traceable to USP 1366002
• rodzina API: lidocaine
• Certyfikat analizy: current certificate can be downloaded
• metody: HPLC: suitable; gas chromatography (GC): suitable
• Zastosowanie: cleaning products; cosmetics; food and beverages; personal care; pharmaceutical (small molecule)
• Format: neat
• temp. przechowywania: 2-30°C
• ciąg SMILES: CCN(CC)CC(=O)Nc1c(C)cccc1C
• InChI: 1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
• Klucz InChI: NNJVILVZKWQKPM-UHFFFAOYSA-N
• informacje o genach: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Opis

Opis ogólny

Lidocaine is a drug, which serves as a potential candidate in the treatment of cardiac arrhythmias.[1]

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Lidocaine is a local anesthetic drug that can exhibit pronounced antiarrhythmic and anticonvulsant effects. It is known as a central nervous system depressant and shows sedative, analgesic and anticonvulsant properties.[2]

Zastosowanie

Lidocaine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.[3][2][4]

Lidocaine may be used as an internal standard in the determination of perhexiline in human serum samples using gas liquid chromatography (GLC).[5]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Działania biochem./fizjol.

Na⁺ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.

Na⁺ channel blocker; class IB antiarrhythmic.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAC0142 in the slot below. This is an example certificate only and may not be the lot that you receive.

Polecane produkty

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H302
• Zwroty wskazujące środki ostrożności: P264 - P270 - P301 + P312 - P501
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable