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I3377

Isoniazid

analytical standard, ≥99% (TLC)

Synonim(y):

4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide

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Gabaryty przesyłkiSKUDostępnośćCena netto
5 g
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80,20 zł
50 g
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
433,00 zł
250 g
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862,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C6H7N3O
Numer CAS:
Masa cząsteczkowa:
137.14
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-214-6
Beilstein/REAXYS Number:
119374
MDL number:

80,20 zł


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grade

analytical standard

Quality Level

assay

≥99% (TLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

171-173 °C (lit.)

fluorescence

λex 360 nm; λem 450 nm (thiol adduct)

antibiotic activity spectrum

mycobacteria

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

NNC(=O)c1ccncc1

InChI

1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)

InChI key

QRXWMOHMRWLFEY-UHFFFAOYSA-N

General description

Chemical structure: pyridine
Isoniazid is a type of drug possessing antimycobacterial activity.It is used in the treatment of tuberculosis.[1]

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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Ta pozycja
PHR1932I05000001349706
Isoniazid analytical standard, ≥99% (TLC)

Supelco

I3377

Isoniazid

Isoniazid European Pharmacopoeia (EP) Reference Standard

I0500000

Isoniazid

Isoniazid United States Pharmacopeia (USP) Reference Standard

USP

1349706

Isoniazid

grade

analytical standard

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

format

neat

format

-

format

neat

format

neat

fluorescence

λex 360 nm; λem 450 nm (thiol adduct)

fluorescence

-

fluorescence

-

fluorescence

-

antibiotic activity spectrum

mycobacteria

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-

mp

171-173 °C (lit.)

mp

171-173 °C (lit.)

mp

171-173 °C (lit.)

mp

171-173 °C (lit.)

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

-


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pictograms

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signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Skin Irrit. 2

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów



Ram Shankar Upadhayaya et al.
European journal of medicinal chemistry, 45(5), 1854-1867 (2010-02-09)
We have designed and synthesized both the quinoline and naphthalene based molecules influenced by the unique structural make-up of mefloquine and TMC207, respectively. These compounds were evaluated for their anti-mycobacterial activity against drug sensitive Mycobacterium tuberculosis H37Rv in vitro at
Isoniazid could be used for antibiotic-loaded bone cement for musculoskeletal tuberculosis: an in vitro study
Han DC, et al.
Clinical Orthopaedics and Related Research, 471(7), 2400-2406 (2013)
Chang Dong Han et al.
Clinical orthopaedics and related research, 471(7), 2400-2406 (2013-03-19)
Antibiotic-loaded bone cement (ALBC) has been used in serious cases of musculoskeletal tuberculosis, but the type and amount of antibiotic that should be used in ALBC have not been determined. We therefore determined the (1) elution characteristics and (2) antimycobacterial



Numer pozycji handlu globalnego

SKUNUMER GTIN
I3377-250G04061835564163
I3377-5G04061835564187
I3377-50G04061835564170

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How do I prepare a 10mL solution of the drug at a concentration of 10mg/mL

    1 answer
    1. 100 mg of material would need to be dissolved in 10 total mL of solvent. Solubility is tested at 50 mg/mL in water, so water is suitable at this concentration. It should also be soluble in ethanol up to 20 mg/mL or so, but this is not tested or guaranteed by us. Please keep in mind that this is an R&D-grade material intended for use as an analytical standard - not for use as a drug for human or animal application.

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