C0225000

Calcitriol

European Pharmacopoeia (EP) Reference Standard

• Synonim(y): 1α,25-Dihydroxyvitamin D₃, 1α,25-Dihydroxycholecalciferol, Calcitriol
• Wzór empiryczny (zapis Hilla): C₂₇H₄₄O₃
• Numer CAS: 32222-06-3
• Masa cząsteczkowa: 416.64
• Beilstein: 7559394
• Numer MDL: MFCD00867079
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329774770
• NACRES: NA.24

Właściwości

• pochodzenie biologiczne: sheep wool (grease)
• klasa czystości: pharmaceutical primary standard
• agency: EP
• rodzina API: calcitriol
• Formularz: solid
• producent / nazwa handlowa: EDQM
• metody: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Zastosowanie: pharmaceutical (small molecule)
• Format: neat
• temp. przechowywania: −20°C
• ciąg SMILES: [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
• InChI: 1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
• Klucz InChI: GMRQFYUYWCNGIN-NKMMMXOESA-N
• informacje o genach: human ... VDR(7421)

Opis

Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the authority of the issuing pharmacopoeia. For further information and support please go to the website of the issuing pharmacopoeia.

Calcitriol is a biologically active metabolite of vitamin D, formed via hydroxylation of calcidiol in the kidney.[1]

Zastosowanie

Calcitriol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Działania biochem./fizjol.

Biologically active form of vitamin D₃ in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D₃ has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D₃ acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Opakowanie

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Inne uwagi

Sales restrictions may apply.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H300 + H310 + H330,H372
• Zwroty wskazujące środki ostrożności: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Klasyfikacja zagrożeń: Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - STOT RE 1
• Kod klasy składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable