17936

1α,25-Dihydroxyvitamin D₃

≥97.0% (HPLC)

• Synonim(y): 1α,25-Dihydroxycholecalciferol, Calcitriol
• Wzór empiryczny (zapis Hilla): C₂₇H₄₄O₃
• Numer CAS: 32222-06-3
• Masa cząsteczkowa: 416.64
• Beilstein: 7559394
• Numer WE: 250-963-8
• Numer MDL: MFCD00867079
• Kod UNSPSC: 12352205
• eCl@ss: 34058003
• Identyfikator substancji w PubChem: 57647688
• NACRES: NA.79

Właściwości

• Poziom jakości: 200
• Próba: ≥97.0% (HPLC)
• Formularz: crystals
• kolor: white to off-white
• temp. przechowywania: −70°C
• ciąg SMILES: [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
• InChI: 1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
• Klucz InChI: GMRQFYUYWCNGIN-NKMMMXOESA-N
• informacje o genach: human ... VDR(7421)

Opis

Opis ogólny

1α,25-Dihydroxyvitamin D₃, also referred as calcitriol, is a calcitrophic hormone.[1] It is the most biologically active metabolite of vitamin D produced in proximal tubular cells in the kidney.[2][3]

Zastosowanie

1α,25-Dihydroxyvitamin D₃ has been used to study its effect on transplantation success of human muscle precursor cells (hMPCs) in severe combined immunodeficient (SCID) mice in-vitro.[4]

Działania biochem./fizjol.

1α,25-Dihydroxyvitamin D₃ modulates energy metabolism by facilitating various metabolic processes, such as Ca²⁺ signaling and modulation of glucocorticoids, by affecting adipocyte apoptosis and by regulating the expression and production of multiple cytokines.[1] In addition, it also modulates phosphorus homeostasis through actions in the intestine, kidney and bone.[5] 1α,25-Dihydroxyvitamin D₃ exhibits antiproliferative effects and is used as a potent therapeutic for human prostate cancer.[6]

Biologically active form of vitamin D₃ in calcium absorption and deposition.

Biologically active form of vitamin D₃ in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D₃ has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D₃ acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Opakowanie

Bottomless glass bottle. Contents are inside inserted fused cone.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H300 + H310 + H330,H372
• Zwroty wskazujące środki ostrożności: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Klasyfikacja zagrożeń: Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - STOT RE 1
• Kod klasy składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges