67667

Kynurenic acid

analytical standard

• Synonim(y): KYNA, 4-Hydroxyquinoline-2-carboxylic acid
• Wzór empiryczny (zapis Hilla): C₁₀H₇NO₃
• Numer CAS: 492-27-3
• Masa cząsteczkowa: 189.17
• Beilstein: 147451
• Numer WE: 207-751-5
• Numer MDL: MFCD00006753
• Kod UNSPSC: 41116107

Właściwości

• klasa czystości: analytical standard
• Próba: ≥98.0% (HPLC)
• okres trwałości: limited shelf life, expiry date on the label
• mp: 275 °C (dec.) (lit.)
• Zastosowanie: clinical testing
• ciąg SMILES: OC(=O)c1cc(O)c2ccccc2n1
• InChI: 1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
• Klucz InChI: HCZHHEIFKROPDY-UHFFFAOYSA-N

Opis

Opis ogólny

Kynurenic acid, a tryptophan metabolite, is a naturally occurring NMDA-receptor and an α7 nicotinic acetylcholine receptor antagonist in the human brain with preferential action at both of the glycine (Gly) binding sites of the N-methyl D-aspartate (NMDA) and α7 nicotinic acetylcholine receptors. This implies that the compound can have a physiological interaction with glutaminergic and cholinergic neurotransmission in the brain. Kynurenic acid is reported to be found in elevated levels in the cerebrospinal fluid of patients with schizophrenia. Its anticonvulsant and neuroprotective properties are experimentally reported.

Zastosowanie

Kynurenic acid may be used as an analytical standard for the quantification of the analyte in serum samples, food and honeybee products using high-performance liquid chromatography with fluorescence detection.

Polecane produkty

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable