580551

Tautomycin, Streptomyces spiroverticillatus

Tautomycin, CAS 109946-35-2, is a potent inhibitor of protein phosphatase 1, 2A, and smooth muscle endogenous phosphatase (IC₅₀ = 1 nM, 10 nM, and 6 nM, respectively). Mixture of two isomers.

• Synonim(y): Tautomycin, Streptomyces spiroverticillatus
• Wzór empiryczny (zapis Hilla): C₄₁H₆₆O₁₃
• Numer CAS: 109946-35-2
• Masa cząsteczkowa: 766.95
• Kod UNSPSC: 12352200

Właściwości

• Poziom jakości: 100
• Próba: ≥97% (HPLC)
• Postać: lyophilized (thin film)
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; desiccated; protect from light
• rozpuszczalność: chloroform: soluble; ethanol: soluble; methanol: soluble
• Warunki transportu: ambient
• temp. przechowywania: −20°C
• InChI: 1S/C41H66O13/c1-21(2)36(51-34(47)20-31(45)35-27(8)39(48)52-40(35)49)38(50-10)32(46)19-30(44)26(7)29(43)13-11-24(5)37-25(6)16-18-41(54-37)17-15-23(4)33(53-41)14-12-22(3)28(9)42/h21-26,29,31-33,36-38,43,45-46H,11-20H2,1-10H3/t22-,23+,24+,25-,26-,29-,31+,32+,33-,36+,37-,38+,41+/m0/s1
• Klucz InChI: RFCWHQNNCOJYTR-IRCAEPKSSA-N

Opis

Opis ogólny

Mixture of two isomers. Potent inhibitor of protein phosphatases and useful for studies involving protein phosphorylation. Inhibits protein phosphatase 1 (IC₅₀ = 1 nM), protein phosphatase 2A (IC₅₀ = 10 nM), and smooth muscle endogenous phosphatase (IC₅₀ = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase.

Mixture of two isomers. Potent inhibitor of protein phosphatases. Inhibits protein phosphatase 1 (IC₅₀ = 1 nM), protein phosphatase 2A (IC₅₀ = 10 nM), and smooth muscle endogenous phosphatase (IC₅₀ = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C.

Działania biochem./fizjol.

Cell permeable: no

Primary Target
PP1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1 nM, 10 nM, 6 nM, against protein phosphatase 1, protein phosphatase 2A, and smooth muscle endogenous phosphatase, respectively

Ostrzeżenie

Toxicity: Highly Toxic (H)

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.







From Catalog:

Desc. Field- removed ". . .and useful for studies involving protein phosphorylation"

- removed ". . .or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase"

Inne uwagi

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

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Kikuchi, K., et al. 1999. Int. J. Mol. Med.4, 395.
Sheppeck, J.E., et al. 1997. J. Org. Chem.62, 387.
Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett.6, 3.
Gong, M.C., et al. 1992. J. Biol. Chem.267, 14662.
Suganuma, M., et al. 1992. Toxicon30, 873.
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Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H300
• Zwroty wskazujące środki ostrożności: P264 - P270 - P301 + P310 - P405 - P501
• Klasyfikacja zagrożeń: Acute Tox. 2 Oral
• Kod klasy składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable