537075

(±)-Propranolol, Hydrochloride

A highly lipophilic agent that blocks both β₁ and β₂ adrenergic receptors with equal potency.

• Synonim(y): (±)-Propranolol, Hydrochloride, (±)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol, HCl
• Wzór empiryczny (zapis Hilla): C₁₆H₂₁NO₂ · xHCl
• Numer CAS: 3506-09-0
• Masa cząsteczkowa: 259.34 (free base basis)
• UNSPSC Code: 12352200
• Assay: ≥97% (HPLC)
• Form: powder
• Storage condition: OK to freeze

Właściwości

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: methanol: soluble, water: soluble
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C17H23NO2.ClH/c1-13(2)10-18-11-15(19)12-20-17-9-5-7-14-6-3-4-8-16(14)17;/h3-9,13,15,18-19H,10-12H2,1-2H3;1H
• InChI key: RTTYPFXTLKDXPS-UHFFFAOYSA-N

Opis

General description

A highly lipophilic agent that blocks both β₁ and β₂ adrenergic receptors with equal potency. Has no effect on α-adrenergic receptors. Also binds to 5HT-1B receptors with high affinity (K_i = 17 nM) in contrast to 5HT-1D receptors (K_i = 10.2 µM). Readily enters the central nervous system. Blocks phospholipase D-derived diacylglycerol (DAG) formation by inhibiting phosphatidate phosphohydrolase. Useful tool for discriminating between phospholipase D- or phospholipase C-mediated DAG production. An anti-hypertensive agent that is also used in the treatment of cardiac arrhythmias.

Biochem/physiol Actions

Cell permeable: no

Primary Target
β1 and β2 adrenergic receptors

Product does not compete with ATP.

Reversible: no

Target K_i: 17 nM for 5HT-1B receptors

Preparation Note

Following reconstitution, aliquot and freeze (-20°C).

Other Notes

Fujita, K., et al. 1996. FEBS Lett.395, 293.
Glennon, R.A., et al. 1996. Mol. Pharmacol.49, 198.
Thompson, N.T., et al. 1991. Trends Pharmacol. Sci.12, 404.
Hoffman, B.B., and Lefkowitz, R.J. 1990. in The Pharmacological Basis of Therapeutics (Gilman, A.G., et al., Eds.) p. 221, Pergamon Press, New York.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable