5.09884

Myristoylated-FEEERA, mP6

• Synonim(y): Myristoylated-FEEERA, mP6, Integrin Signaling Inhibitor I, mP6
• Wzór empiryczny (zapis Hilla): C₄₇H₇₅N₉O₁₄
• Masa cząsteczkowa: 990.15
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Próba: ≥98% (HPLC)
• Poziom jakości: 100
• Postać: powder
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; desiccated (hygroscopic); protect from light
• kolor: white
• rozpuszczalność: DMSO: 100 mg/mL
• temp. przechowywania: −70°C

Opis

Opis ogólny

A cell-permeable myristoylated hexapeptide derived from EXE-motif-containing integrin β3 subunit that selectively inhibits integrin outside-in signaling without affecting inside-out signaling . Shown to specifically block the interaction of Gα3 and integrin β3 subunit resulting in the inhibition of Gα13-dependent early phase outside-in signaling. Selectively inhibits thrombosis without affecting haemostasis.

A cell-permeable myristoylated hexapeptide derived from EXE-motif-containing integrin β3 subunit that selectively inhibits integrin outside-in signaling without affecting inside-out signaling . Shown to specifically block the interaction of Gα3 and integrin β3 subunit resulting in the inhibition of Gα13-dependent early phase outside-in signaling. Selectively inhibits thrombosis without affecting haemostasis.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Działania biochem./fizjol.

Cell permeable: yes

Primary Target
platelet integrin →IIb→3

Reversible: yes

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Sekwencja

FEEERA

Rekonstytucja

Following reconstitution, aliquot and freeze (-207deg;C). Stock solutions are stable for up to 3 months at -20°C.

Inne uwagi

Shen, B., et al. 2013. Nature503, 131.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable