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239835

Sigma-Aldrich

Cyclosporin A, Tolypocladium inflatum

Cyclosporin A, CAS 59865-13-3, is an immunosuppressant that induces apoptosis in rat thymocytes and in the murine B cell lymphoma cell line, WEH1-231. Induces cardiomyocytes formation from ESCs.

Synonim(y):

Cyclosporin A, Tolypocladium inflatum

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About This Item

Wzór empiryczny (zapis Hilla):
C62H111N11O12
Numer CAS:
Masa cząsteczkowa:
1202.61
Numer MDL:
Kod UNSPSC:
12352200

Poziom jakości

Próba

≥97% dry basis

Formularz

solid

producent / nazwa handlowa

Calbiochem®

warunki przechowywania

OK to freeze

kolor

white to off-white

rozpuszczalność

DMSO: 25 mg/mL
chloroform: soluble
ethanol: soluble
methanol: soluble

Warunki transportu

ambient

temp. przechowywania

2-8°C

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+

Klucz InChI

PMATZTZNYRCHOR-IMVLJIQESA-N

Opis ogólny

Cyclic oligopeptide with immunosuppressant properties. Induces apoptosis in rat thymocytes and in the murine B cell lymphoma cell line, WEH1-231. However, prevents anti-IgM and ionomycin-induced apoptosis in BLB cell lines. The complex of cyclosporin A with cyclophilin inhibits protein phosphatase 2B with nanomolar affinity. Inhibits nitric oxide synthesis induced by interleukin-1α, lipopolysaccharides, and TNF-α. Induces cardiomyocytes from embryonic stem cells.
Material is a nonpolar cyclic oligopeptide with immunosuppressant activity. Appears to act via interaction with the intracellular protein cyclophilin. The cyclophilin-cyclosporin A complex is a potent inhibitor of the protein phosphatase activity of calcineurin (protein phosphatase 2B, PP2B). Induces apoptosis in rat thymocytes and in the murine B-cell lymphoma cell line, WEHI-231; however, it prevents anti-IgM and ionomycin-induced apoptosis in BLB cell lines. Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides, and TNFα. Induces cardiomyocytes from embryonic stem cells.

Działania biochem./fizjol.

Cell permeable: no
Primary Target
NOS induced by interlukin-1-α
Product does not compete with ATP.
Reversible: no

Ostrzeżenie

Toxicity: Carcinogenic / Teratogenic (D)

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Inne uwagi

Yan, P., et al. 2008. Biochem. Biophys. Res. Commun.in press.
Hattori, Y., and Naranishi, N. 1995. Cell Immunol.165, 7.
Marumo, T., et al. 1995. Hypertension25, 764.
Crabtree, G.R., and Clipstone, N.A. 1994. Annu. Rev. Biochem.63, 1045.
Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA91, 7350.
Montague, J.W., et al. 1994. J. Biol. Chem.269, 18877.
Fast, D.J., et al. 1993. J.Interferon Res. 13, 235.
Liu, J. 1993. Trends Pharmacol. Sci. 14, 182.
Fruman, D.A., et al. 1992. Proc. Natl. Acad. Sci. USA89, 3686.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Ta strona może zawierać tekst przetłumaczony maszynowo.

Piktogramy

Health hazardExclamation mark

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

Zwroty wskazujące środki ostrożności

Klasyfikacja zagrożeń

Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

Kod klasy składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Klasa zagrożenia wodnego (WGK)

WGK 3


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