P2928

パキシリン

powder, ≥98% (HPLC)

• 実験式（ヒル表記法）: C₂₇H₃₃NO₄
• CAS番号: 57186-25-1
• 分子量: 435.56
• MDL番号: MFCD00083464
• UNSPSCコード: 12352200
• PubChem Substance ID: 24898374
• NACRES: NA.77

特性

• 品質水準: 200
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: faintly yellow
• 保管温度: 2-8°C
• SMILES記法: CC(C)(O)C1OC2CCC3(C)C(O)(CCC4Cc5c([nH]c6ccccc56)C34C)C2=CC1=O
• InChI: 1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1
• InChI Key: ACNHBCIZLNNLRS-UBGQALKQSA-N

詳細

詳細

Paxilline is an indole diterpene metabolite produced by fungi. It has a functionalized pentacyclic core and is a template for the synthesis of a wide variety of derivatives.

アプリケーション

Paxilline has been used to block large conductance calcium activated potassium channels (BKCa) in murine smooth muscle cells and in myometrial cells of uterine samples. Paxilline acts as an agonist and activates liver X receptor in atlantic salmon.

生物化学的／生理学的作用

Paxilline is a selective blocker of high-conductance Ca₂⁺-activated (Maxi-K) potassium channels. It also blocks big potassium (BK) channels.

特徴および利点

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

その他情報

Penicillium paxilliの主な毒素です。

安全性情報

• ピクトグラム: GHS06,GHS05
• シグナルワード: Danger
• 危険有害性情報: H301 + H311 + H331,H315,H318,H335
• 注意書き: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges