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形状
solid
色
white
溶解性
H2O: soluble
ethanol: soluble
SMILES記法
Cl[H].CN1CCC(=CC1)c2ccccc2C
InChI
1S/C13H17N.ClH/c1-11-5-3-4-6-13(11)12-7-9-14(2)10-8-12;/h3-7H,8-10H2,1-2H3;1H
InChI Key
QLIQCKBPYIWPTE-UHFFFAOYSA-N
アプリケーション
1-Methyl-4-(2′-methylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride has been used to study its effect on core temperature in C57BL/6J mice.
生物化学的／生理学的作用
1-Methyl-4-(2′-methylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) is a tertiary amine. It is widely used to induce experimental parkinsonism in mice.
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 3 Oral
保管分類コード
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
個人用保護具 (PPE)
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
適用法令
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Jan Code
M103-10MG:
M103-BULK:
M103-50MG:
M103-VAR:
試験成績書（COA）
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E Sundström et al.
Pharmacology & toxicology, 81(5), 226-231 (1997-12-13)
Three steps in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity were compared with the neurodegenerative effects of the toxin in mice and rats. Firstly, we compared the neurotoxicity of MPTP, mediated by monoamine oxidase (MAO)-B, to that of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-CH3-MPTP), an analogue oxidized by
M Mizobuchi et al.
Brain research, 612(1-2), 319-321 (1993-05-28)
Neuroendocrine abnormality of the hypothalamic-pituitary-adrenal axis was investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated dogs as a model of Parkinson's disease. Blood samples were collected every 4 h for 3-4 days before MPTP treatment, around 2 and 4 weeks after the treatment of
M Del Zompo et al.
British journal of pharmacology, 109(2), 411-414 (1993-06-01)
1. In the present study we provide evidence for a saturable, Mg2+/ATP- and temperature-dependent, tetrabenazine-, dopamine-, and amphetamine-sensitive uptake of 1-methyl-4-phenylpyridinium ion (MPP+) in synaptic vesicles from mouse striatum. 2. Similarity in the properties of the vesicular uptake suggests that
S K Youngster et al.
European journal of pharmacology, 122(2), 283-287 (1986-03-18)
The administration to mice of 1-methyl-4-(2'-methylphenyl)-1,2,3, 6-tetrahydropyridine (2'-CH3-MPTP), a substituted analog of the dopaminergic neurotoxin MPTP caused even more dopaminergic toxicity than MPTP itself. Under conditions in which MPTP was relatively ineffective (i.e. two injections per day of 0.113 mmol/kg
T May
Neuroscience letters, 162(1-2), 55-58 (1993-11-12)
The in vitro binding of [3H]pargyline and [3H]harman ([3H]1-methyl-beta-carboline) to monoamine oxidase A (MAO-A; EC 1.4.3.4) on membranes of rat cerebral cortex was evaluated. Displacement of the [3H]pargyline binding on MAO-A (L(-)-deprenyl suppressed binding to MAO-B) by harman, 1-methyl-4-phenylpyridinium (MPP+)
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