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製品名
Leu-Ser-Lys-Leu-NH2, ≥95% (HPLC)
アッセイ
≥95% (HPLC)
フォーム
powder
テクニック
mass spectrometry (MS): suitable
色
white
保管温度
−20°C
SMILES記法
CC(C)C[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(N)=O
InChI
1S/C21H42N6O5/c1-12(2)9-14(23)19(30)27-17(11-28)21(32)25-15(7-5-6-8-22)20(31)26-16(18(24)29)10-13(3)4/h12-17,28H,5-11,22-23H2,1-4H3,(H2,24,29)(H,25,32)(H,26,31)(H,27,30)/t14-,15-,16-,17-/m0/s1
InChI Key
YOKXDNNIFSAXBY-QAETUUGQSA-N
Amino Acid Sequence
Leu-Ser-Lys-Leu-NH2
生物化学的／生理学的作用
Leu-Ser-Lys-Leu-NH2 (LSKL-NH2) is found at the C-terminal of the neurotoxic wasp venom α-pompilidotoxin (α-PMTX). A similar peptide Leu-Ser-Lys-Leu (LSKL) is a used to study the activation of TGF-β1 via thrombospondin.
Used to study the activation of TGF-β1
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
L5538-BULK:
L5538-250MG:
L5538-VAR:
L5538-250MG-PW:
P2Y4/TSP-1/TGF-β1/pSmad2/3 pathway contributes to acute generalized seizures induced by kainic acid.
Yurong Zhang et al.
Brain research bulletin, 149, 106-119 (2019-04-22)
Epilepsy is accompanied by angiogenesis and blood-brain barrier (BBB) disruption. The transforming growth factor-β1 (TGF-β1)/phosphorylated small mothers against decapentaplegic 2 and 3 (pSmad2/3)/vascular endothelial growth factor (VEGF) pathway, activated by thrombospondin-1 (TSP-1), which is further regulated by Y type P2
Xi-sheng Xie et al.
Archives of pharmacal research, 33(2), 275-284 (2010-03-03)
The effects of LSKL, the peptide antagonist of thrombospondin-1 (TSP-1), on renal interstitial fibrosis in rats subjected to unilateral ureteral obstruction (UUO) were investigated. Rats were divided randomly into three groups (n = 20 each): UUO group, sham-operation group and
K Konno et al.
Biochemical and biophysical research communications, 250(3), 612-616 (1998-10-24)
Novel peptide neurotoxins, alpha- and beta-pompilidotoxins (alpha- and beta-PMTXs), were purified from the venoms of the solitary wasps Anoplius samariensis and Batozonellus maculifrons. Their structures were analyzed mostly by MALDI-TOF-MS, which were corroborated by solid-phase synthesis. alpha-PMTX, with 13 amino
Emanuele Schiavon et al.
The FEBS journal, 277(4), 918-930 (2010-01-12)
Pompilidotoxins (PMTXs, alpha and beta) are small peptides consisting of 13 amino acids purified from the venom of the solitary wasps Anoplius samariensis (alpha-PMTX) and Batozonellus maculifrons (beta-PMTX). They are known to facilitate synaptic transmission in the lobster neuromuscular junction
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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