SML1290

PA-824

≥98% (HPLC)

• 別名: (6S)- 6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-Imidazo[2,1-b][1,3]oxazine, (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, (S)-PA 824, PA 824, Pretomanid
• 実験式（ヒル表記法）: C₁₄H₁₂F₃N₃O₅
• CAS番号: 187235-37-6
• 分子量: 359.26
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 光学活性: [α]/D -40 to -48°, c = 1 in methanol
• 色: white to brown
• 溶解性: DMSO: 5 mg/mL, clear (warmed)
• 保管温度: −20°C
• SMILES記法: FC(F)(F)Oc1ccc(cc1)CO[C@H]2C[n]3c(nc(c3)[N+](=O)[O-])OC2
• InChI: 1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1
• InChI Key: ZLHZLMOSPGACSZ-NSHDSACASA-N

詳細

生物化学的／生理学的作用

Anti-tuberculosis drug

PA-824 is a pro-drug that has an effect on both replicating and non-replicating Mycobacterium tuberculosis. It is activated by deazaflavin (cofactor F420)-dependent nitroreducase.[1]

PA-824 is an anti-tuberculosis drug that exhibits multiple mechanism of action, including both cell wall inhibition and respiratory poisoning.

PA-824 is an anti-tuberculosis drug.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable