K1388

KT 5823

≥85% (HPLC), lyophilized powder

• 実験式（ヒル表記法）: C₂₉H₂₅N₃O₅
• CAS番号: 126643-37-6
• 分子量: 495.53
• MDL番号: MFCD09878278
• UNSPSCコード: 12352200
• PubChem Substance ID: 24896206
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥85% (HPLC)
• フォーム: lyophilized powder
• 色: white
• 溶解性: ethyl acetate: 5 mg/mL
• 保管温度: 2-8°C
• SMILES記法: COC(=O)[C@]1(CC2O[C@]1(C)n3c4ccccc4c5c6CN(C)C(=O)c6c7c8ccccc8n2c7c35)OC
• InChI: 1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
• InChI Key: QTYMDECKVKSGSM-YMUMJAELSA-N

詳細

詳細

KT5823 is a protein kinase inhibitor. It inhibits guanosine monophosphate (GMP)-dependent protein kinase activity (cGK).[1] It is a staurosporine compound, which promotes the thyroid-stimulating hormone and regulates Na⁺/I⁻ symporter (NIS) expression.[2]

アプリケーション

KT 5823 has been used as cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor in cortical cultures,[3] cortical neurons[4] and in mouse brain capillary endothelial cells.[5]

生物化学的／生理学的作用

PKGの選択的インヒビタ-です。

特徴および利点

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)