420321

KT5823

Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM).

• 別名: KT5823, PKG Inhibitor VII
• 実験式（ヒル表記法）: C₂₉H₂₅N₃O₅
• CAS番号: 126643-37-6
• 分子量: 495.53
• MDL番号: MFCD09878278
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 1 mg/mL; DMF: soluble
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: [n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)CN(C7=O)C)cccc6)[C@@H]5O[C@]1([C@@](C5)(OC)C(=O)OC)C
• InChI: 1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
• InChI Key: QTYMDECKVKSGSM-YMUMJAELSA-N

詳細

詳細

Highly specific cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM). Inhibits protein kinase C (K_i = 4.0 µM) and protein kinase A (K_i >10.0 µM) at higher concentrations.

Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
PKG

Product competes with ATP.

Reversible: yes

Target K_i: 234 nM against protein kinase G

警告

Toxicity: Standard Handling (A)

調製ノート

Further dilute with aqueous buffers just prior to use.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Grider, J.R. 1993. Am. J. Physiol.264, G334.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable