G117

グリピジド

solid

• 別名: 1-シクロヘキシル-3-{4-[2-(5-メチルピラジン-2-カルボキサミド)エチル]フェニルスルホニル}尿素
• 実験式（ヒル表記法）: C₂₁H₂₇N₅O₄S
• CAS番号: 29094-61-9
• 分子量: 445.54
• EC Number: 249-427-6
• MDL番号: MFCD00072159
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277839
• NACRES: NA.77

特性

• フォーム: solid
• 品質水準: 100
• 色: white
• 溶解性: methanol: 1.9 mg/mL; DMSO: 48 mg/mL
• SMILES記法: Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
• InChI: 1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
• InChI Key: ZJJXGWJIGJFDTL-UHFFFAOYSA-N
• 遺伝子情報: human ... ABCC8(6833) , KCNJ1(3758) , KCNJ11(3767)

詳細

詳細

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) codes for a renal outer medullary potassium channel (ROMK1, Kir1.1).[1] Glipizide is an antidiabetic drug, that is used to treat type II diabetes.(5)

アプリケーション

Glipizide has been used in:

• chick embryo yolk sac membrane (YSM) and chorioallantoic membrane (CAM) assay[2]
• MCF-7 breast cancer assay on chorioallantoic membrane (CAM)[2]
• metastasis assays[2][3]
• rat aortic ring assay[3]
• in vivo matrigel plug assay
• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay[3]
• flow cytometry[3]
• western blotting[3]

生物化学的／生理学的作用

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) plays a vital role in potassium balance.[4] It is an ATP-dependent K⁺ channel blocker. The encoded protein is liable for the elimination of potassium in exchange for the absorption of sodium by the epithelial sodium channel (ENaC).[1] Mutation in KCNJ1 is linked with several diseases, such as, antenatal Bartter syndrome and diabetes.[4] Glipizide helps to repress the development of tumors and metastasis by preventing angiogenesis.[2]

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)