D5287

2′-デオキシイノシン

≥98%

• 別名: 9-(2-デオキシ-β-D-リボフラノシル)ヒポキサンチン
• 実験式（ヒル表記法）: C₁₀H₁₂N₄O₄
• CAS番号: 890-38-0
• 分子量: 252.23
• Beilstein: 33517
• EC Number: 212-964-1
• MDL番号: MFCD00005762
• UNSPSCコード: 41106305
• PubChem Substance ID: 24893935
• NACRES: NA.51

特性

• 由来生物: synthetic (organic)
• 品質水準: 200
• アッセイ: ≥98%
• フォーム: powder
• 不純物: inosine, essentially free
• 溶解性: 1 M NH₄OH: 50 mg/mL, clear, colorless
• 保管温度: −20°C
• SMILES記法: OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3C(=O)NC=Nc23
• InChI: 1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1
• InChI Key: VGONTNSXDCQUGY-RRKCRQDMSA-N

詳細

アプリケーション

2′-Deoxyinosine has been used in the quantification of nucleoside forms of DNA lesion in a single DNA sample by liquid chromatography tandem mass spectrometry (LC-MS/MS).[1] It has also been used as a standard for high performance liquid chromatography analysis.[2]

生物化学的／生理学的作用

2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. 2′-Deoxyinosine in DNA can arise from deamination of adenosine. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability.

2′-Deoxyinosine is a nucleoside form of hypoxanthine. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species.[2] 2′-deoxyinosine is formed from nitrosative deamination by N₂O₃.[1]

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)