A2731

AMG 9810

≥98% (HPLC), powder

• 別名: 2E-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-Propenamide
• 実験式（ヒル表記法）: C₂₁H₂₃NO₃
• CAS番号: 545395-94-6
• 分子量: 337.41
• MDL番号: MFCD00955103
• UNSPSCコード: 12352203
• PubChem Substance ID: 329770793
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: >5 mg/mL
• オーガナイザー: Amgen
• 保管温度: 2-8°C
• SMILES記法: CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1
• InChI: 1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+
• InChI Key: GZTFUVZVLYUPRG-IZZDOVSWSA-N

詳細

生物化学的／生理学的作用

AMG 9810 is a potent, non-vanilloid, antagonist of the TRPV1 receptor. IC₅₀ = 17 nM.

AMG 9810 is the cinnamide TRPV1 (vanilloid receptor 1) antagonist, that can prevent eye wiping behavior, stimulated by capsaicin and can inverse hyperalgesia in an animal model of inflammatory pain. It possesses antihyperalgesic properties.[1]

特徴および利点

This compound was developed by Amgen. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H413
• 注意書き: P264 - P270 - P273 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Chronic 4
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves