A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).
生物化学的／生理学的作用
Cell permeable: yes
Primary Target NADPH oxidase
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Irritant (B)
再構成
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
その他情報
Abid, M.R., et al. 2000. FEBS Lett.486, 252. Muijsers, R.B., et al. 2000. Br. J. Pharmacol.130, 932. Lapperre, T.S., et al. 1999. FEBS Lett.443, 235. Supinski, G., et al. 1999, J. Appl. Physiol.87, 776. van der Goes, A., et al. 1998. J. Neuroimmunol.92, 67. Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther.3, 3.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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